UniProt:Q96AH8 RAB7B

chain
  • chain:1-199
checksum 161C41ABC0EBA529
comment
  • FUNCTION Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.INTERACTION Recruited to phagosomes containing S.aureus or M.tuberculosis.TISSUE SPECIFICITY Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 152783
description
  • recommendedName: Ras-related protein Rab-7b
displayName UniProt:Q96AH8 RAB7B
geneName
  • RAB7B
identifier Q96AH8
isSequenceChanged false
keyword
  • Cytoplasmic vesicle
  • Endosome
  • Golgi apparatus
  • GTP-binding
  • Lipoprotein
  • Lysosome
  • Membrane
  • Nucleotide-binding
  • Phosphoprotein
  • Prenylation
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RAB7B
otherIdentifier
  • 11725570_a_at
  • 11754764_a_at
  • 1553982_PM_a_at
  • 1553982_a_at
  • 17126286
  • 17126288
  • 230266_PM_at
  • 230266_at
  • 338382
  • 4057777
  • 4065397
  • 4112424
  • 4121470
  • 46105_at
  • 78918_at
  • 8180340
  • 82456_at
  • 91241_at
  • ADDON002889.hg
  • ADDON002890.hg
  • A_23_P252541
  • A_23_P61590
  • A_23_P84281
  • GE589512
  • GE83512
  • GE88302
  • GO:0000166
  • GO:0002682
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005764
  • GO:0005768
  • GO:0005770
  • GO:0005794
  • GO:0005802
  • GO:0006355
  • GO:0008333
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016787
  • GO:0030670
  • GO:0031090
  • GO:0031410
  • GO:0031902
  • GO:0032755
  • GO:0034144
  • GO:0034164
  • GO:0034499
  • GO:0045335
  • GO:0045654
  • GO:0051092
  • GO:0061024
  • GO:0071346
  • GO:0090385
  • HMNXSV003008901
  • HMNXSV003030422
  • Hs.55405.0.A1_3p_at
  • Hs2.135717.1.S1_3p_s_at
  • ILMN_1771688
  • PH_hs_0031254
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB7B_HUMAN
sequenceLength 199
species [Species:48887] Homo sapiens
stId uniprot:Q96AH8
url http://purl.uniprot.org/uniprot/Q96AH8
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