Reactome | UniProt:Q96AC1 FERMT2

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UniProt:Q96AC1 FERMT2 Show undefined attributes

chain	chain:1-680
checksum	BAFF5AF2CD91C43C
comment	FUNCTION Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.SUBUNIT Interacts with ILK (By similarity). Interacts with FBLIM1. Interacts with ITGB1 and ITGB3. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1.INTERACTION Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.ALTERNATIVE PRODUCTS Ubiquitous. Found in numerous tumor tissues.INDUCTION By serum in lung fetal fibroblast cultured cells.DOMAIN The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.DOMAIN The PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3,4,5-trisphosphate, and has lower affinity for phosphatidylinositol-4,5-bisphosphate (PubMed:22030399).DOMAIN The N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues.MISCELLANEOUS May be due to an exon inclusion and an intron retention.SIMILARITY Belongs to the kindlin family.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION FERMT2 entry
crossReference	[DatabaseIdentifier:12462785] RefSeq:NP_001128472.1 [DatabaseIdentifier:12462786] RefSeq:NP_006823.1 [DatabaseIdentifier:12462784] RefSeq:NP_001128471.1 [DatabaseIdentifier:12287409] Pharos - Targets:Q96AC1 [DatabaseIdentifier:12267979] PRO:Q96AC1 [DatabaseIdentifier:12190468] PDB:2LKO [DatabaseIdentifier:12190467] PDB:6XTJ [DatabaseIdentifier:12190470] PDB:4F7H [DatabaseIdentifier:12156777] PDB:6U4N [DatabaseIdentifier:12190471] PDB:2LGX [DatabaseIdentifier:12190469] PDB:2MSU [DatabaseIdentifier:12127173] OpenTargets:ENSG00000073712 [DatabaseIdentifier:11842581] HPA:ENSG00000073712-FERMT2 [DatabaseIdentifier:11829364] HMDB Protein:HMDBP14135 [DatabaseIdentifier:11805192] GlyGen:Q96AC1 [DatabaseIdentifier:11789554] GeneCards:FERMT2 [DatabaseIdentifier:11757290] ENSEMBL:ENST00000395631 [DatabaseIdentifier:11757289] ENSEMBL:ENST00000341590 [DatabaseIdentifier:11757292] ENSEMBL:ENST00000553373 [DatabaseIdentifier:11757293] ENSEMBL:ENST00000343279 [DatabaseIdentifier:11757291] ENSEMBL:ENST00000399304 [DatabaseIdentifier:11634591] ENSEMBL:ENSP00000342858 [DatabaseIdentifier:11634590] ENSEMBL:ENSP00000378993 [DatabaseIdentifier:11634592] ENSEMBL:ENSP00000451084 [DatabaseIdentifier:11634593] ENSEMBL:ENSP00000382243 [DatabaseIdentifier:11634594] ENSEMBL:ENSP00000340391 [DatabaseIdentifier:11517221] ENSEMBL:ENSG00000073712
databaseName	UniProt
dbId	98372
description	recommendedName: Fermitin family homolog 2 alternativeName: Kindlin-2 alternativeName: Mitogen-inducible gene 2 protein shortName: MIG-2 alternativeName: Pleckstrin homology domain-containing family C member 1 shortName: PH domain-containing family C member 1
displayName	UniProt:Q96AC1 FERMT2
geneName	FERMT2 KIND2 MIG2 PLEKHC1
identifier	Q96AC1
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell adhesion Cell junction Cell membrane Cell projection Cell shape Cytoplasm Cytoskeleton Lipid-binding Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Wnt signaling pathway
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	FERMT2
otherIdentifier	10979 11718179_a_at 11718180_s_at 11718181_s_at 11737221_a_at 16793067 209209_PM_s_at 209209_s_at 209210_PM_s_at 209210_s_at 214212_PM_x_at 214212_x_at 3376773 3564918 3564920 3564921 3564922 3564923 3564924 3564925 3564926 3564927 3564928 3564929 3564931 3564932 3564936 3564941 3564942 3564944 3564948 3564949 3564950 3564951 3564952 3564956 3564957 3564960 3564961 3564963 3564964 3564966 3564967 3564968 3564969 3564970 3564971 3564972 3564974 36577_at 71961_at 7979204 A_23_P88347 A_33_P3344477 A_33_P3344482 GE60378 GO:0001725 GO:0003013 GO:0003779 GO:0005178 GO:0005515 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005912 GO:0005925 GO:0005938 GO:0007155 GO:0007160 GO:0007179 GO:0007229 GO:0008092 GO:0008289 GO:0008360 GO:0009898 GO:0009986 GO:0010718 GO:0016020 GO:0016055 GO:0019901 GO:0022604 GO:0030054 GO:0030335 GO:0031258 GO:0031674 GO:0033622 GO:0033625 GO:0034330 GO:0034334 GO:0034446 GO:0034713 GO:0035025 GO:0042995 GO:0043116 GO:0043539 GO:0045599 GO:0045669 GO:0046332 GO:0048041 GO:0048856 GO:0051015 GO:0051496 GO:0051894 GO:0051897 GO:0060173 GO:0065003 GO:0070161 GO:0070374 GO:0072657 GO:0098772 GO:0120283 GO:1900026 GO:1900182 GO:1902414 GO:1902462 GO:1903691 HMNXSV003032031 HMNXSV003047592 Hs.75260.0.S1_3p_a_at Hs.75260.1.S1_3p_a_at ILMN_1695290 PH_hs_0023340 TC14001144.hg TC14002011.hg Z24725_at g505032_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-430275] FERMT2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12713334] UCSC:Q96AC1 FERMT2 [ReferenceDNASequence:12112075] OMIM:607746 FERMT2 [ReferenceDNASequence:12095060] NCBI Gene:10979 FERMT2 [ReferenceDNASequence:12010967] Monarch:10979 FERMT2 [ReferenceDNASequence:11918089] KEGG:hsa:10979 FERMT2 [ReferenceDNASequence:11821210] HGNC:15767 FERMT2 [ReferenceDNASequence:11432102] dbSNP Gene:10979 FERMT2 [ReferenceDNASequence:11416323] CTD Gene:10979 FERMT2 [ReferenceDNASequence:11395822] COSMIC - genes:FERMT2 FERMT2 [ReferenceDNASequence:11381178] BioGPS Gene:10979 FERMT2 [ReferenceDNASequence:ensembl:ENSG00000073712] ENSEMBL:ENSG00000073712 FERMT2
referenceTranscript	[ReferenceRNASequence:12644254] RefSeq:NM_001134999.2 FERMT2 [ReferenceRNASequence:12644255] RefSeq:NM_006832.3 FERMT2 [ReferenceRNASequence:12644256] RefSeq:NM_001135000.2 FERMT2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	FERM2_HUMAN B5TJY2 Q14840 Q86TY7
sequenceLength	680
species	[Species:48887] Homo sapiens
stId	uniprot:Q96AC1
url	http://purl.uniprot.org/uniprot/Q96AC1

Referrals

(interactor)	[UndirectedInteraction:11140509] UniProt:Q96AC1 <-> UniProt:A0A0H3NFP4 (IntAct) [UndirectedInteraction:11140505] UniProt:Q96AC1 <-> UniProt:Q8TBZ3 (IntAct) [UndirectedInteraction:11140503] UniProt:Q96AC1 <-> UniProt:Q6ZW61 (IntAct) [UndirectedInteraction:11140501] UniProt:Q96AC1 <-> UniProt:P15884 (IntAct) [UndirectedInteraction:11140499] UniProt:Q96AC1 <-> UniProt:P35222 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-430275] FERMT2 [cytosol]