UniProt:Q969X2 ST6GALNAC6

chain
  • chain:1-333
checksum 5DB6FFA7D7A707C0
comment
  • FUNCTION Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity).CATALYTIC ACTIVITY a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)CATALYTIC ACTIVITY N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP + H(+)CATALYTIC ACTIVITY a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H(+)CATALYTIC ACTIVITY a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)CATALYTIC ACTIVITY a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)CATALYTIC ACTIVITY 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein] + CMP + H(+)CATALYTIC ACTIVITY 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)BIOPHYSICOCHEMICAL PROPERTIES Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.INDUCTION Down-regulated in renal cancers.MISCELLANEOUS The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270).SIMILARITY Belongs to the glycosyltransferase 29 family.SEQUENCE CAUTION ST6GalNAc VI
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 248338
description
  • recommendedName: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ecNumber evidence="5 6"2.4.99.- alternativeName: GalNAc alpha-2,6-sialyltransferase VI alternativeName: fullName evidence="7 12"ST6GalNAc VI shortName: ST6GalNAcVI shortName: hST6GalNAc VI alternativeName: Sialyltransferase 7F shortName: SIAT7-F
displayName UniProt:Q969X2 ST6GALNAC6
geneName
  • ST6GALNAC6
  • SIAT7F
  • UNQ708/PRO1359
identifier Q969X2
isSequenceChanged false
keyword
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Lipid metabolism
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Sialic acid
  • Signal-anchor
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • ST6GALNAC6
otherIdentifier
  • 11718363_a_at
  • 11718364_a_at
  • 11749989_a_at
  • 17098642
  • 222571_PM_at
  • 222571_at
  • 30815
  • 3226159
  • 3226161
  • 3226162
  • 3226163
  • 3226164
  • 3226165
  • 3226166
  • 3226168
  • 3226169
  • 3226170
  • 3226172
  • 3226173
  • 3226174
  • 3226175
  • 3226176
  • 3226177
  • 3226178
  • 3226179
  • 3226180
  • 3226183
  • 3226184
  • 48111_at
  • 8164304
  • 8180339
  • 83273_at
  • 89236_at
  • A_23_P315892
  • A_33_P3254751
  • GE479968
  • GE484294
  • GE53878
  • GE557236
  • GE797092
  • GO:0000139
  • GO:0001574
  • GO:0001665
  • GO:0005515
  • GO:0005737
  • GO:0005794
  • GO:0005886
  • GO:0005975
  • GO:0006486
  • GO:0006629
  • GO:0006672
  • GO:0006677
  • GO:0006687
  • GO:0006688
  • GO:0008373
  • GO:0009100
  • GO:0009311
  • GO:0009312
  • GO:0009988
  • GO:0016020
  • GO:0016740
  • GO:0016757
  • GO:1901135
  • HMNXSV003028785
  • HMNXSV003042507
  • HMNXSV003046910
  • HMNXSV003053493
  • Hs.109672.0.S2_3p_at
  • ILMN_1691736
  • PH_hs_0006050
  • TC09002921.hg
  • p16630
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SIA7F_HUMAN
  • B3KQ01
  • Q5T9C4
  • Q5T9C5
  • Q9H8A2
  • Q9ULB8
sequenceLength 333
species [Species:48887] Homo sapiens
stId uniprot:Q969X2
url http://purl.uniprot.org/uniprot/Q969X2
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