Reactome | UniProt:Q93074 MED12

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UniProt:Q93074 MED12 Show undefined attributes

chain	chain:1-2177
checksum	7492B07BA0F6EA9D
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3.INTERACTION Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Mediator complex subunit 12 family.
crossReference	[DatabaseIdentifier:11494361] ENSEMBL:ENSG00000184634 [DatabaseIdentifier:12417168] RefSeq:NP_005111.2 [DatabaseIdentifier:12286841] Pharos - Targets:Q93074 [DatabaseIdentifier:12246893] PRO:Q93074 [DatabaseIdentifier:12156735] PDB:8TQC [DatabaseIdentifier:12156736] PDB:8TQ2 [DatabaseIdentifier:12139978] PDB:8TQW [DatabaseIdentifier:12137846] Orphanet:MED12 [DatabaseIdentifier:12126587] OpenTargets:ENSG00000184634 [DatabaseIdentifier:11602128] ENSEMBL:ENSP00000363193 [DatabaseIdentifier:11602127] ENSEMBL:ENSP00000508427 [DatabaseIdentifier:11602129] ENSEMBL:ENSP00000363215 [DatabaseIdentifier:11724828] ENSEMBL:ENST00000374080 [DatabaseIdentifier:11724827] ENSEMBL:ENST00000374102 [DatabaseIdentifier:11724826] ENSEMBL:ENST00000692304 [DatabaseIdentifier:11788967] GeneCards:MED12 [DatabaseIdentifier:11804593] GlyGen:Q93074 [DatabaseIdentifier:11841993] HPA:ENSG00000184634-MED12
databaseName	UniProt
dbId	65526
description	recommendedName: Mediator of RNA polymerase II transcription subunit 12 alternativeName: Activator-recruited cofactor 240 kDa component shortName: ARC240 alternativeName: CAG repeat protein 45 alternativeName: Mediator complex subunit 12 alternativeName: OPA-containing protein alternativeName: Thyroid hormone receptor-associated protein complex 230 kDa component shortName: Trap230 alternativeName: Trinucleotide repeat-containing gene 11 protein
displayName	UniProt:Q93074 MED12
geneName	MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230
identifier	Q93074
isSequenceChanged	false
keyword	3D-structure Acetylation Activator Alternative splicing Direct protein sequencing Disease variant Intellectual disability Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	MED12
otherIdentifier	11723361_a_at 17104587 203506_PM_s_at 203506_s_at 211342_PM_x_at 211342_x_at 216071_PM_x_at 216071_x_at 3980759 3980760 3980761 3980763 3980764 3980765 3980766 3980767 3980768 3980769 3980770 3980771 3980772 3980773 3980774 3980775 3980776 3980777 3980778 3980779 3980780 3980781 3980782 3980783 3980784 3980785 3980786 3980787 3980788 3980789 3980790 3980791 3980792 3980793 3980794 3980795 3980796 3980797 3980798 3980799 3980800 3980801 3980802 3980803 3980804 3980805 3980806 3980807 3980808 3980809 3980810 3980811 3980812 3980813 3980814 3980815 3980816 3980817 3980818 3980819 3980820 3980821 3980822 3980823 3980824 3980825 3980826 3980827 3980828 3980829 3980830 3980831 3980832 3980834 3980836 3980837 3980838 3980839 3980840 3980841 3980842 3980843 3980844 3980845 3980846 3980847 3980848 3980849 3980850 40998_at 8168215 9968 A_14_P135849 A_23_P73702 D83783_at GE729352 GE81473 GO:0000151 GO:0000978 GO:0001756 GO:0001843 GO:0003682 GO:0003712 GO:0003713 GO:0003824 GO:0005515 GO:0005634 GO:0005654 GO:0006355 GO:0006357 GO:0007492 GO:0007507 GO:0008013 GO:0014003 GO:0014044 GO:0016020 GO:0016567 GO:0016592 GO:0016740 GO:0021510 GO:0021915 GO:0035019 GO:0036342 GO:0042809 GO:0045893 GO:0045944 GO:0046966 GO:0048568 GO:0048702 GO:0048856 GO:0060071 GO:0060261 GO:0061630 GO:0090245 GO:0140096 GO:1990403 GO:1990508 HMNXSV003048336 ILMN_1793386 PH_hs_0024789 TC0X000382.hg TC0X001752.hg TC0X001753.hg g4827041_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212343] MED12 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11899135] KEGG:hsa:9968 MED12 [ReferenceDNASequence:12752682] UCSC:Q93074 MED12 [ReferenceDNASequence:12111566] OMIM:300188 MED12 [ReferenceDNASequence:12073919] NCBI Gene:9968 MED12 [ReferenceDNASequence:11989826] Monarch:9968 MED12 [ReferenceDNASequence:ensembl:ENSG00000184634] ENSEMBL:ENSG00000184634 MED12 [ReferenceDNASequence:11360037] BioGPS Gene:9968 MED12 [ReferenceDNASequence:11401763] COSMIC - genes:MED12 MED12 [ReferenceDNASequence:11415459] CTD Gene:9968 MED12 [ReferenceDNASequence:11439143] dbSNP Gene:9968 MED12 [ReferenceDNASequence:11820619] HGNC:11957 MED12
referenceTranscript	[ReferenceRNASequence:12598826] RefSeq:NM_005120.3 MED12
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MED12_HUMAN O15410 O75557 Q9UHV6 Q9UND7
sequenceLength	2177
species	[Species:48887] Homo sapiens
stId	uniprot:Q93074
url	http://purl.uniprot.org/uniprot/Q93074

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-212343] MED12 [nucleoplasm]

(interactor)