Reactome | UniProt:Q92997 DVL3

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UniProt:Q92997 DVL3 Show undefined attributes

chain	chain:1-716
checksum	B1A55EBF9507D06E
comment	FUNCTION Involved in the signal transduction pathway mediated by multiple Wnt genes.SUBUNIT Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2 (PubMed:25805136). Interacts with DAAM2 (By similarity).INTERACTION Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.PTM Phosphorylated by CSNK1D.PTM Arginine methylation may function as a switch in regulation of function in Wnt signaling.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the DSH family.
crossReference	[DatabaseIdentifier:11519426] ENSEMBL:ENSG00000161202 [DatabaseIdentifier:12816012] ZINC target:Q92997 [DatabaseIdentifier:12812637] ZINC - Substances:DVL3_HUMAN [DatabaseIdentifier:12467662] RefSeq:NP_004414.3 [DatabaseIdentifier:12288519] Pharos - Targets:Q92997 [DatabaseIdentifier:12270032] PRO:Q92997 [DatabaseIdentifier:12204226] PDB:6ZC7 [DatabaseIdentifier:12204229] PDB:6ZC4 [DatabaseIdentifier:12204228] PDB:6ZBQ [DatabaseIdentifier:12204230] PDB:8S6A [DatabaseIdentifier:12204225] PDB:6ZC8 [DatabaseIdentifier:12204227] PDB:6ZBZ [DatabaseIdentifier:12171043] PDB:6V7O [DatabaseIdentifier:12204231] PDB:6ZC3 [DatabaseIdentifier:12136610] Orphanet:DVL3 [DatabaseIdentifier:12128297] OpenTargets:ENSG00000161202 [DatabaseIdentifier:11843683] HPA:ENSG00000161202-DVL3 [DatabaseIdentifier:11806618] GlyGen:Q92997 [DatabaseIdentifier:11790679] GeneCards:DVL3 [DatabaseIdentifier:11760428] ENSEMBL:ENST00000431765 [DatabaseIdentifier:11760429] ENSEMBL:ENST00000313143 [DatabaseIdentifier:11637730] ENSEMBL:ENSP00000405885 [DatabaseIdentifier:11637729] ENSEMBL:ENSP00000316054
databaseName	UniProt
dbId	53998
description	recommendedName: Segment polarity protein dishevelled homolog DVL-3 shortName: Dishevelled-3 alternativeName: DSH homolog 3
displayName	UniProt:Q92997 DVL3
geneName	DVL3 KIAA0208
identifier	Q92997
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cytoplasm Developmental protein Dwarfism Methylation Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Wnt signaling pathway
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	DVL3
otherIdentifier	11721506_a_at 11721507_at 11721508_at 11748468_a_at 16948712 1857 201907_PM_x_at 201908_PM_at 201908_at 2655439 2655440 2655441 2655442 2655444 2655445 2655446 2655447 2655448 2655449 2655450 2655451 2655452 2655453 2655454 2655455 2655456 2655457 2655458 2655459 2655460 2655461 2655462 2655463 2655464 2655466 2655467 2655468 2655469 2655470 2655471 2655472 2655473 2655474 2655475 2655477 2655478 40873_at 43731_at 8084323 A_14_P135109 A_14_P136001 A_23_P218884 A_24_P283000 A_24_P291588 D86963_at GE58335 GO:0000785 GO:0002020 GO:0005102 GO:0005109 GO:0005515 GO:0005737 GO:0005829 GO:0006355 GO:0007264 GO:0008013 GO:0009410 GO:0016055 GO:0031267 GO:0032880 GO:0032956 GO:0035556 GO:0035567 GO:0045893 GO:0045944 GO:0046330 GO:0050821 GO:0060070 GO:0060071 GO:0150012 HMNXSV003024421 ILMN_2137464 PH_hs_0024349 TC03000993.hg g1277022_3p_s_at g6806886_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3772400] pp-DVL3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-201680] p-DVL3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-201678] DVL3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4652688] ub-DVL3 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11418162] CTD Gene:1857 DVL3 [ReferenceDNASequence:12767240] UCSC:Q92997 DVL3 [ReferenceDNASequence:12113072] OMIM:601368 DVL3 [ReferenceDNASequence:12097260] NCBI Gene:1857 DVL3 [ReferenceDNASequence:12013167] Monarch:1857 DVL3 [ReferenceDNASequence:11920081] KEGG:hsa:1857 DVL3 [ReferenceDNASequence:11822340] HGNC:3087 DVL3 [ReferenceDNASequence:11441295] dbSNP Gene:1857 DVL3 [ReferenceDNASequence:ensembl:ENSG00000161202] ENSEMBL:ENSG00000161202 DVL3 [ReferenceDNASequence:11383378] BioGPS Gene:1857 DVL3 [ReferenceDNASequence:11403667] COSMIC - genes:DVL3 DVL3
referenceTranscript	[ReferenceRNASequence:12649133] RefSeq:NM_004423.3 DVL3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	DVL3_HUMAN B4E3E5 D3DNT0 O14642 Q13531 Q8N5E9 Q92607
sequenceLength	716
species	[Species:48887] Homo sapiens
stId	uniprot:Q92997
url	http://purl.uniprot.org/uniprot/Q92997

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3772400] pp-DVL3 [cytosol] [EntityWithAccessionedSequence:R-HSA-201680] p-DVL3 [cytosol] [EntityWithAccessionedSequence:R-HSA-201678] DVL3 [cytosol] [EntityWithAccessionedSequence:R-HSA-4652688] ub-DVL3 [cytosol]
(referenceSequence)	[ModifiedResidue:3772386] phosphorylated residue at unknown position [GroupModifiedResidue:4652686] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
(interactor)	[UndirectedInteraction:11133365] UniProt:O43463 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11135579] UniProt:O75689 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11137099] UniProt:O14641 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11142177] UniProt:Q13573 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11142235] UniProt:P19544 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11159825] UniProt:O43159 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11160675] UniProt:O14640 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11161977] UniProt:Q96MU7 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11163679] UniProt:Q9GZV5 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11167011] UniProt:P49674 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11177841] UniProt:Q14498 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11211291] UniProt:Q15696 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11217961] UniProt:Q9UIH9 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11219919] UniProt:O95926 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11233395] UniProt:Q8NAV1 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11235475] UniProt:P61289 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11238245] UniProt:O15169 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11238813] UniProt:O76024 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11241087] UniProt:Q96EB6 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11242331] UniProt:O43474 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11244617] UniProt:Q12933 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11248081] UniProt:Q9ULK5 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11249125] UniProt:Q99633 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11252149] UniProt:Q8WUD4 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11257415] UniProt:P48730 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11271309] UniProt:P26368 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11273729] UniProt:P05067 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11276375] UniProt:O95363 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11278451] UniProt:Q9UPV0 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11280715] UniProt:Q9UBU9 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11283889] UniProt:Q9UGY1 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11291385] UniProt:O14503 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11294843] UniProt:P68400 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11296741] UniProt:P54646 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11305475] UniProt:Q5S007 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11305849] UniProt:Q96T60 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11306681] UniProt:P23025 <-> UniProt:Q92997 (IntAct) [UndirectedInteraction:11306957] UniProt:P31273 <-> UniProt:Q92997 (IntAct)

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