UniProt:Q92800 EZH1

chain
  • chain:1-747
checksum 7CFC52269CDA011B
comment
  • FUNCTION Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.CATALYTIC ACTIVITY L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)SUBUNIT Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2 (PubMed:19026781). The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM) (PubMed:19026781). Interacts with EZHIP; the interaction blocks EZH1 methyltransferase activity (PubMed:31451685).INTERACTION Colocalizes with trimethylated 'Lys-27' of histone H3.ALTERNATIVE PRODUCTS Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
crossReference
databaseName UniProt
dbId 54554
description
  • recommendedName: Histone-lysine N-methyltransferase EZH1 ecNumber evidence="5"2.1.1.356 alternativeName: ENX-2 alternativeName: Enhancer of zeste homolog 1
displayName UniProt:Q92800 EZH1
geneName
  • EZH1
  • KIAA0388
identifier Q92800
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Chromatin regulator
  • Isopeptide bond
  • Methyltransferase
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repressor
  • S-adenosyl-L-methionine
  • Transcription
  • Transcription regulation
  • Transferase
  • Ubl conjugation
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • EZH1
otherIdentifier
  • 11717323_a_at
  • 11717324_at
  • 11763781_a_at
  • 16845222
  • 203249_3p_at
  • 203249_PM_at
  • 203249_at
  • 211310_3p_at
  • 211310_PM_at
  • 211310_at
  • 2145
  • 239197_PM_s_at
  • 239197_s_at
  • 239198_PM_at
  • 239198_at
  • 32259_PM_at
  • 32259_at
  • 3758071
  • 3758077
  • 3758079
  • 3758080
  • 3758081
  • 3758082
  • 3758083
  • 3758084
  • 3758085
  • 3758086
  • 3758087
  • 3758089
  • 3758090
  • 3758092
  • 3758093
  • 3758094
  • 3758095
  • 3758096
  • 3758097
  • 3758098
  • 3758099
  • 3758100
  • 3758101
  • 3758103
  • 3758104
  • 3758105
  • 3758107
  • 46841_at
  • 8015685
  • A_23_P428219
  • GE62570
  • GE81100
  • GO:0000122
  • GO:0000781
  • GO:0000792
  • GO:0003682
  • GO:0003714
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0008168
  • GO:0009653
  • GO:0016279
  • GO:0016740
  • GO:0021766
  • GO:0031491
  • GO:0031507
  • GO:0031509
  • GO:0032259
  • GO:0035098
  • GO:0042054
  • GO:0042393
  • GO:0045944
  • GO:0046976
  • GO:0048856
  • GO:0060090
  • GO:0140096
  • GO:0140693
  • GO:0140951
  • HMNXSV003053645
  • Hs.47564.0.S1_3p_at
  • ILMN_1791436
  • PH_hs_0011495
  • TC17001540.hg
  • U50315_at
  • g2224716_3p_at
  • g2224716_3p_s_at
  • g2934699_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EZH1_HUMAN
  • A6NCH6
  • B4DIJ1
  • B4DIZ7
  • B4DSS2
  • B4E3R7
  • O43287
  • Q14459
  • Q53XP3
sequenceLength 747
species [Species:48887] Homo sapiens
stId uniprot:Q92800
url http://purl.uniprot.org/uniprot/Q92800
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