UniProt:Q92785 DPF2

chain
  • initiator methionine:1
  • chain:2-391
checksum 1044B4D3036075FC
comment
  • FUNCTION Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684).SUBUNIT Interacts with the nucleosomes, in particular nucleosomes bearing histone H3 crotonylated at 'Lys-14' (H3K14cr) for which DPF2 has high affinity (PubMed:27775714). Also interacts (via PHD-type zinc finger domains) with histone H3 butyrylated at 'Lys-14' (H3K14bu), histone H3 propionylated at 'Lys-14' (H3K14pr), and histone H3 acetylated at 'Lys-14' (H3K14ac) (PubMed:27775714, PubMed:28533407, PubMed:29429572). Interacts with histone H3 acetylated at 'Lys-9' (H3K9ac), histone H3 di-methylated at 'Lys-9' (H3K9me2), and histone H3 tri-methylated at 'Lys-9' (H3K9me3) (PubMed:29429572). Interacts with histone H4 acetylated at 'Lys-12' (H4K12ac) (PubMed:29429572). Interacts with histone H4 acetylated at 'Lys-16' (H4K16ac) (PubMed:28533407). Interacts with SWI/SNF complex components (PubMed:20460684, PubMed:28533407). Interacts with SMARCA2, SMARCA4, SMARCB1 and SMARCD1 (PubMed:20460684). Interacts with SMARCC1, SMARCC2 and ACTL6A (PubMed:28533407). Interacts with RUNX1 (PubMed:28533407).INTERACTION Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the requiem/DPF family.
crossReference
databaseName UniProt
dbId 62938
description
  • recommendedName: Zinc finger protein ubi-d4 alternativeName: Apoptosis response zinc finger protein alternativeName: BRG1-associated factor 45D shortName: BAF45D alternativeName: D4, zinc and double PHD fingers family 2 alternativeName: Protein requiem
displayName UniProt:Q92785 DPF2
geneName
  • DPF2
  • BAF45D
  • REQ
  • UBID4
identifier Q92785
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Apoptosis
  • Chromatin regulator
  • Cytoplasm
  • Disease variant
  • Intellectual disability
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • DPF2
otherIdentifier
  • 11739444_a_at
  • 11739445_s_at
  • 11753079_a_at
  • 11753080_s_at
  • 11754311_a_at
  • 16726832
  • 202116_PM_at
  • 202116_at
  • 244361_PM_at
  • 244361_at
  • 2974134
  • 3335086
  • 3335090
  • 3335091
  • 3335094
  • 3335095
  • 3335096
  • 3335097
  • 3335098
  • 3335099
  • 3335100
  • 3335101
  • 3335102
  • 3335103
  • 3335104
  • 3335105
  • 3335106
  • 3335107
  • 3335108
  • 3335109
  • 3335110
  • 3335111
  • 3335113
  • 3335114
  • 3335115
  • 3335116
  • 3335121
  • 3335125
  • 3335126
  • 3335127
  • 3335128
  • 39688_at
  • 5977
  • 7941243
  • 7941255
  • 83055_at
  • A_14_P111831
  • A_14_P130308
  • A_23_P127446
  • GE54037
  • GO:0000122
  • GO:0000785
  • GO:0003714
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005813
  • GO:0005815
  • GO:0005829
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0006357
  • GO:0006915
  • GO:0007399
  • GO:0008270
  • GO:0016514
  • GO:0030071
  • GO:0046872
  • GO:0048856
  • GO:0070316
  • GO:0071565
  • GO:0097190
  • GO:0140015
  • GO:0140046
  • GO:1902459
  • GO:1905454
  • GO:2000045
  • GO:2000781
  • GO:2000819
  • HMNXSV003004560
  • Hs.148479.0.A1_3p_at
  • ILMN_1734317
  • PH_hs_0001301
  • TC11000624.hg
  • TC11000625.hg
  • U94585_at
  • g10862706_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • REQU_HUMAN
  • A8K7C9
  • B4DT58
sequenceLength 391
species [Species:48887] Homo sapiens
stId uniprot:Q92785
url http://purl.uniprot.org/uniprot/Q92785
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