UniProt:Q92784 DPF3

chain
  • chain:1-378
checksum 7E6A6FD07A0E4668
comment
  • FUNCTION Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.FUNCTION Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350). Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350). HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350).SUBUNIT Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:18765789). In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789). Interacts with acetylated histones H3 and H4 (PubMed:18765789). Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity).SUBUNIT Interacts with HDGFL2, SMARCA4/BRG1/BAF190A, SMARCC1/BAF155 and SMARCD1/BAF60A.SUBCELLULAR LOCATION The PHD-type zinc fingers mediate the binding to acetylated histones.PTM Phosphorylation at Ser-323 enhances its interaction with HDGFL2.MISCELLANEOUS Lacks PHD-type zinc fingers and does not bind to acetylated histones H3 and H4.SIMILARITY Belongs to the requiem/DPF family.
crossReference
databaseName UniProt
dbId 62934
description
  • recommendedName: Zinc finger protein DPF3 alternativeName: BRG1-associated factor 45C shortName: BAF45C alternativeName: Zinc finger protein cer-d4
displayName UniProt:Q92784 DPF3
geneName
  • DPF3
  • BAF45C
  • CERD4
identifier Q92784
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • Chromatin regulator
  • Isopeptide bond
  • Metal-binding
  • Myogenesis
  • Neurogenesis
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • DPF3
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DPF3_HUMAN
  • A8MSI3
  • B7Z276
  • F5H575
  • Q32UJ0
  • Q6P9E6
  • Q6ZT41
  • Q9H7Y5
sequenceLength 378
species [Species:48887] Homo sapiens
stId uniprot:Q92784
url http://purl.uniprot.org/uniprot/Q92784
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