UniProt:Q92781 RDH5

chain
  • chain:1-318
checksum 2CE24343F2EEA4B7
comment
  • FUNCTION Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:11675386, PubMed:9115228, PubMed:9931293). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:29541409, PubMed:9931293).CATALYTIC ACTIVITY 11-cis-retinol + NAD(+) = 11-cis-retinal + NADH + H(+)CATALYTIC ACTIVITY 9-cis-retinol + NAD(+) = 9-cis-retinal + NADH + H(+)CATALYTIC ACTIVITY 13-cis-retinol + NAD(+) = 13-cis-retinal + NADH + H(+)CATALYTIC ACTIVITY androsterone + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)CATALYTIC ACTIVITY 5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)ACTIVITY REGULATION Inhibited by 9-cis-, 13-cis- and all-trans-retinoic acids, with the most potent inhibitor being 13-cis-retinoic acid. Weakly inhibited by oleic acid.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.5-8.0 for 9-cis retinol dehydrogenase activity.PATHWAY Cofactor metabolism; retinol metabolism.SUBUNIT Homodimer.SUBCELLULAR LOCATION Widely expressed. In the eye, abundant in the retinal pigment epithelium.DOMAIN The last 8 amino acids of the C-terminal tail are important for a proper localization as well as for the in vivo enzymatic activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family.
crossReference
databaseName UniProt
dbId 62906
description
  • recommendedName: Retinol dehydrogenase 5 ecNumber evidence="19 21"1.1.1.209 ecNumber evidence="6 12 21"1.1.1.315 ecNumber evidence="21"1.1.1.53 alternativeName: fullName evidence="23"11-cis retinol dehydrogenase shortName: 11-cis RDH shortName: 11-cis RoDH alternativeName: 9-cis retinol dehydrogenase shortName: 9cRDH alternativeName: fullName evidence="22"Short chain dehydrogenase/reductase family 9C member 5
displayName UniProt:Q92781 RDH5
geneName
  • RDH5
  • HSD17B9
  • RDH1
  • SDR9C5
identifier Q92781
isSequenceChanged false
keyword
  • Disease variant
  • Endoplasmic reticulum
  • Glycoprotein
  • Lipid metabolism
  • Membrane
  • NAD
  • Oxidoreductase
  • Proteomics identification
  • Reference proteome
  • Sensory transduction
  • Steroid metabolism
  • Transmembrane
  • Transmembrane helix
  • Vision
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • RDH5
otherIdentifier
  • 11724965_at
  • 11724966_s_at
  • 11762774_at
  • 210106_PM_at
  • 210106_at
  • 236291_PM_at
  • 236291_at
  • 32727_at
  • 3416922
  • 3416923
  • 3416924
  • 3416925
  • 3416926
  • 3416927
  • 3416928
  • 3416929
  • 3416930
  • 3416931
  • 3416932
  • 3416934
  • 3416935
  • 3416936
  • 5959
  • 7956018
  • 87407_at
  • A_14_P107578
  • A_14_P121101
  • A_24_P218814
  • A_32_P80198
  • GE54293
  • GO:0001523
  • GO:0004745
  • GO:0005783
  • GO:0005788
  • GO:0005789
  • GO:0006629
  • GO:0007601
  • GO:0008202
  • GO:0016020
  • GO:0016491
  • GO:0016616
  • GO:0042572
  • GO:0042803
  • GO:0044297
  • GO:0047023
  • GO:0047044
  • GO:0050877
  • GO:0106429
  • HMNXSV003023337
  • Hs.222853.0.S1_3p_at
  • ILMN_1773395
  • TC12003300.hg
  • U89717_at
  • g1616653_3p_at
  • p33670
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RDH5_HUMAN
  • O00179
  • Q8TAI2
sequenceLength 318
species [Species:48887] Homo sapiens
stId uniprot:Q92781
url http://purl.uniprot.org/uniprot/Q92781
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