Reactome | UniProt:Q92754 TFAP2C

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UniProt:Q92754 TFAP2C Show undefined attributes

chain	chain:1-450
checksum	2D4F5FBC269A34A8
comment	FUNCTION Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532).SUBUNIT Binds DNA as a dimer (PubMed:11694877). Can form homodimers or heterodimers with other AP-2 family members (PubMed:11694877). Interacts with WWOX (PubMed:15548692). Interacts with UBE2I (PubMed:12072434). Interacts with KCTD1; this interaction represses transcription activation (PubMed:19115315). Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (PubMed:11694877, PubMed:12586840). Interacts with CITED4 (PubMed:11744733). Interacts with MTA1 (PubMed:24413532).INTERACTION During retinoic acid-mediated differentiation.DOMAIN The PPxY motif mediates interaction with WWOX.PTM Sumoylated on Lys-10; which inhibits transcriptional activity.SIMILARITY Belongs to the AP-2 family.ONLINE INFORMATION Activating protein 2 entry
crossReference	[DatabaseIdentifier:12470466] RefSeq:NP_003213.1 [DatabaseIdentifier:12289460] Pharos - Targets:Q92754 [DatabaseIdentifier:12271380] PRO:Q92754 [DatabaseIdentifier:12129247] OpenTargets:ENSG00000087510 [DatabaseIdentifier:11844619] HPA:ENSG00000087510-TFAP2C [DatabaseIdentifier:11791617] GeneCards:TFAP2C [DatabaseIdentifier:11762307] ENSEMBL:ENST00000201031 [DatabaseIdentifier:11639608] ENSEMBL:ENSP00000201031 [DatabaseIdentifier:11520607] ENSEMBL:ENSG00000087510
databaseName	UniProt
dbId	50088
description	recommendedName: Transcription factor AP-2 gamma shortName: AP2-gamma alternativeName: Activating enhancer-binding protein 2 gamma alternativeName: Transcription factor ERF-1
displayName	UniProt:Q92754 TFAP2C
geneName	TFAP2C
identifier	Q92754
isSequenceChanged	false
keyword	Activator Alternative splicing Direct protein sequencing DNA-binding Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	TFAP2C
otherIdentifier	11726192_at 11749776_a_at 16915091 205286_PM_at 205286_at 205287_PM_s_at 205287_s_at 3890335 3890336 3890337 3890341 3890342 3890343 3890344 3890345 3890348 3890349 3890350 3890351 3890352 40303_at 7022 8063536 A_14_P138033 A_23_P120472 GE59504 GE79079 GO:0000122 GO:0000785 GO:0000977 GO:0000978 GO:0000981 GO:0001227 GO:0001228 GO:0001826 GO:0001829 GO:0001942 GO:0003334 GO:0003677 GO:0003700 GO:0005515 GO:0005634 GO:0005654 GO:0005739 GO:0005829 GO:0006325 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0007267 GO:0008584 GO:0019827 GO:0021877 GO:0021987 GO:0030154 GO:0030718 GO:0030855 GO:0035019 GO:0042127 GO:0043588 GO:0045682 GO:0045814 GO:0045944 GO:0048733 GO:0048856 GO:0048863 GO:0060598 GO:0060750 GO:0140001 GO:1990837 HMNXSV003040291 ILMN_1683891 ILMN_2096784 PH_hs_0020945 TC20000436.hg U85658_at g2058552_3p_at g4507444_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3234071] monoSUMO1-K10-TFAP2C [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8864579] TFAP2C [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3234058] TFAP2C [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12767998] UCSC:Q92754 TFAP2C [ReferenceDNASequence:12113926] OMIM:601602 TFAP2C [ReferenceDNASequence:12098399] NCBI Gene:7022 TFAP2C [ReferenceDNASequence:12014306] Monarch:7022 TFAP2C [ReferenceDNASequence:11921131] KEGG:hsa:7022 TFAP2C [ReferenceDNASequence:11823289] HGNC:11744 TFAP2C [ReferenceDNASequence:11441411] dbSNP Gene:7022 TFAP2C [ReferenceDNASequence:11419416] CTD Gene:7022 TFAP2C [ReferenceDNASequence:11403775] COSMIC - genes:TFAP2C TFAP2C [ReferenceDNASequence:11384517] BioGPS Gene:7022 TFAP2C [ReferenceDNASequence:ensembl:ENSG00000087510] ENSEMBL:ENSG00000087510 TFAP2C
referenceTranscript	[ReferenceRNASequence:12651938] RefSeq:NM_003222.4 TFAP2C
schemaClass	ReferenceGeneProduct
secondaryIdentifier	AP2C_HUMAN B4DWK3 O00685 O00730 Q86V30 Q8IVB6 Q9P1X2
sequenceLength	450
species	[Species:48887] Homo sapiens
stId	uniprot:Q92754
url	http://purl.uniprot.org/uniprot/Q92754

Referrals

(interactor)	[UndirectedInteraction:11163745] UniProt:Q92754 <-> UniProt:Q99967 (IntAct) [UndirectedInteraction:11163743] UniProt:Q92754 <-> UniProt:P03372 (IntAct) [UndirectedInteraction:11163741] UniProt:Q92754 <-> UniProt:P10276 (IntAct) [UndirectedInteraction:11163739] UniProt:Q92754 <-> IntAct:EBI-9679441 (IntAct) [UndirectedInteraction:11163735] UniProt:Q92754 <-> UniProt:P63279 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3234071] monoSUMO1-K10-TFAP2C [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8864579] TFAP2C [cytosol] [EntityWithAccessionedSequence:R-HSA-3234058] TFAP2C [nucleoplasm]
(referenceSequence)	[GroupModifiedResidue:3234103] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 10