Reactome | UniProt:Q92572 AP3S1

Schema > ReferenceGeneProduct > Entries

UniProt:Q92572 AP3S1 Show undefined attributes

chain	chain:1-193
checksum	1EF17F375881288D
comment	FUNCTION Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.SUBUNIT Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).SUBCELLULAR LOCATION Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.TISSUE SPECIFICITY Present in all adult tissues examined.SIMILARITY Belongs to the adaptor complexes small subunit family.
crossReference	[DatabaseIdentifier:12462788] RefSeq:NP_001305019.1 [DatabaseIdentifier:12462790] RefSeq:NP_001305023.1 [DatabaseIdentifier:12462792] RefSeq:NP_001305022.1 [DatabaseIdentifier:12462789] RefSeq:NP_001002924.2 [DatabaseIdentifier:12462791] RefSeq:NP_001305020.1 [DatabaseIdentifier:12462793] RefSeq:NP_001275.1 [DatabaseIdentifier:12287410] Pharos - Targets:Q92572 [DatabaseIdentifier:12267980] PRO:Q92572 [DatabaseIdentifier:12153310] PDB:9C5C [DatabaseIdentifier:12153312] PDB:9C58 [DatabaseIdentifier:12153314] PDB:9C5B [DatabaseIdentifier:12153311] PDB:9C59 [DatabaseIdentifier:12127174] OpenTargets:ENSG00000177879 [DatabaseIdentifier:11842582] HPA:ENSG00000177879-AP3S1 [DatabaseIdentifier:11805193] GlyGen:Q92572 [DatabaseIdentifier:11789555] GeneCards:AP3S1 [DatabaseIdentifier:11757295] ENSEMBL:ENST00000316788 [DatabaseIdentifier:11634596] ENSEMBL:ENSP00000325369 [DatabaseIdentifier:11517223] ENSEMBL:ENSG00000177879
databaseName	UniProt
dbId	84292
description	recommendedName: AP-3 complex subunit sigma-1 alternativeName: AP-3 complex subunit sigma-3A alternativeName: Adaptor-related protein complex 3 subunit sigma-1 alternativeName: Clathrin-associated/assembly/adaptor protein, small 3 alternativeName: Sigma-3A-adaptin shortName: Sigma3A-adaptin alternativeName: Sigma-adaptin 3a
displayName	UniProt:Q92572 AP3S1
geneName	AP3S1 CLAPS3
identifier	Q92572
isSequenceChanged	false
keyword	3D-structure Cytoplasmic vesicle Golgi apparatus Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transport
modified	[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType	Protein
name	AP3S1
otherIdentifier	11742902_s_at 1176 16988174 202442_PM_at 202442_at 2455505 2824873 2824874 2824875 2824876 2824879 2824881 2824882 2824884 2824885 2824886 2824887 2824888 2824895 2824897 2824898 2824899 2824900 38074_at 8107421 A_23_P69958 GE59566 GO:0005515 GO:0005768 GO:0005769 GO:0005794 GO:0006886 GO:0006896 GO:0007018 GO:0008089 GO:0008286 GO:0015031 GO:0016020 GO:0016183 GO:0016192 GO:0030117 GO:0030119 GO:0030123 GO:0030133 GO:0030659 GO:0031410 GO:0035654 GO:0036465 GO:0048490 GO:0060155 GO:0098793 GO:1903232 GO:1904115 HMNXSV003015850 HMNXSV003032930 HMNXSV003055646 ILMN_1658911 ILMN_2311761 PH_hs_0037877 TC05000548.hg U91932_at g4502860_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-434343] AP3S1 [Golgi membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-434205] AP3S1 [cytoplasmic vesicle membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12765975] UCSC:Q92572 AP3S1 [ReferenceDNASequence:12112076] OMIM:601507 AP3S1 [ReferenceDNASequence:12095062] NCBI Gene:1176 AP3S1 [ReferenceDNASequence:12010969] Monarch:1176 AP3S1 [ReferenceDNASequence:11918091] KEGG:hsa:1176 AP3S1 [ReferenceDNASequence:11821211] HGNC:2013 AP3S1 [ReferenceDNASequence:11441163] dbSNP Gene:1176 AP3S1 [ReferenceDNASequence:11416324] CTD Gene:1176 AP3S1 [ReferenceDNASequence:11403543] COSMIC - genes:AP3S1 AP3S1 [ReferenceDNASequence:11381180] BioGPS Gene:1176 AP3S1 [ReferenceDNASequence:ensembl:ENSG00000177879] ENSEMBL:ENSG00000177879 AP3S1
referenceTranscript	[ReferenceRNASequence:12644258] RefSeq:NM_001318093.1 AP3S1 [ReferenceRNASequence:12644259] RefSeq:NM_001318094.1 AP3S1 [ReferenceRNASequence:12644260] RefSeq:NM_001284.4 AP3S1 [ReferenceRNASequence:12644262] RefSeq:NM_001318091.1 AP3S1 [ReferenceRNASequence:12644263] RefSeq:NM_001002924.2 AP3S1 [ReferenceRNASequence:12644261] RefSeq:NM_001318090.1 AP3S1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	AP3S1_HUMAN O00647 O00676 O00721 O00727 Q53XL4 Q6ICQ2
sequenceLength	193
species	[Species:48887] Homo sapiens
stId	uniprot:Q92572
url	http://purl.uniprot.org/uniprot/Q92572

Referrals

(interactor)	[UndirectedInteraction:11260115] UniProt:Q9Y337 <-> UniProt:Q92572 (IntAct) [UndirectedInteraction:11216807] UniProt:Q8N307 <-> UniProt:Q92572 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-434343] AP3S1 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-434205] AP3S1 [cytoplasmic vesicle membrane]