UniProt:Q92541 RTF1

chain
  • chain:1-710
checksum 54CC014655AA22B8
comment
  • FUNCTION Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity).SUBUNIT Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8; the association of RTF1 appears to be less stable than that of other subunits. At least in HeLa cells a N-terminal shorter form of RTF1 is also found in the complex (PubMed:20178742). The PAF1 complex interacts with PHF5A (By similarity).INTERACTION The Plus3 domain mediates single-stranded DNA-binding.CAUTION It is uncertain whether Met-1 or Met-41 is the initiator.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 246725
description
  • recommendedName: RNA polymerase-associated protein RTF1 homolog
displayName UniProt:Q92541 RTF1
geneName
  • RTF1
  • KIAA0252
identifier Q92541
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Coiled coil
  • DNA-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Wnt signaling pathway
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • RTF1
otherIdentifier
  • 11717356_at
  • 11717357_at
  • 11717358_s_at
  • 11717359_at
  • 16799814
  • 212301_PM_at
  • 212301_at
  • 212302_PM_at
  • 212302_at
  • 230832_PM_at
  • 230832_at
  • 23168
  • 3590423
  • 3590424
  • 3590425
  • 3590428
  • 3590430
  • 3590431
  • 3590432
  • 3590433
  • 3590434
  • 3590435
  • 3590436
  • 3590437
  • 3590438
  • 3590440
  • 3590442
  • 3590443
  • 3590444
  • 3590445
  • 3590446
  • 3590447
  • 3590448
  • 3590449
  • 3590450
  • 3590451
  • 3590452
  • 3590453
  • 3590454
  • 3590455
  • 3590456
  • 3590461
  • 3590462
  • 38436_at
  • 77964_at
  • 7982904
  • A_23_P77321
  • A_24_P390403
  • D87440_at
  • GE57396
  • GO:0000122
  • GO:0001711
  • GO:0001832
  • GO:0003677
  • GO:0003697
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0006325
  • GO:0006355
  • GO:0006368
  • GO:0016055
  • GO:0016593
  • GO:0019827
  • HMNXSV003000938
  • Hs.223713.0.A1_3p_at
  • Hs.83419.0.A1_3p_at
  • Hs.83419.0.A2_3p_at
  • ILMN_1791039
  • PH_hs_0004764
  • TC15000308.hg
  • TC15002165.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RTF1_HUMAN
  • Q96BX6
sequenceLength 710
species [Species:48887] Homo sapiens
stId uniprot:Q92541
url http://purl.uniprot.org/uniprot/Q92541
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