Reactome | UniProt:Q8WXI2 CNKSR2

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UniProt:Q8WXI2 CNKSR2 Show undefined attributes

chain	chain:1-1034
checksum	E43DB0D8D72D954C
comment	FUNCTION May function as an adapter protein or regulator of Ras signaling pathways.SUBUNIT Interacts with RAF1, RAB2L and RAL GTPase proteins.INTERACTION Phosphorylated on tyrosine.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CNKSR family.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:12279848] Pharos - Targets:Q8WXI2 [DatabaseIdentifier:12236456] PRO:Q8WXI2 [DatabaseIdentifier:12141581] PDB:3BS5 [DatabaseIdentifier:12141580] PDB:2EAN [DatabaseIdentifier:12135077] Orphanet:CNKSR2 [DatabaseIdentifier:12119511] OpenTargets:ENSG00000149970 [DatabaseIdentifier:11835058] HPA:ENSG00000149970-CNKSR2 [DatabaseIdentifier:11797627] GlyGen:Q8WXI2 [DatabaseIdentifier:11781936] GeneCards:CNKSR2 [DatabaseIdentifier:11651027] ENSEMBL:ENST00000642359 [DatabaseIdentifier:11651025] ENSEMBL:ENST00000543067 [DatabaseIdentifier:11651024] ENSEMBL:ENST00000379510 [DatabaseIdentifier:11651026] ENSEMBL:ENST00000425654 [DatabaseIdentifier:11528327] ENSEMBL:ENSP00000496709 [DatabaseIdentifier:11528328] ENSEMBL:ENSP00000444633 [DatabaseIdentifier:11528326] ENSEMBL:ENSP00000397906 [DatabaseIdentifier:11528325] ENSEMBL:ENSP00000368824 [DatabaseIdentifier:11442777] ENSEMBL:ENSG00000149970
databaseName	UniProt
dbId	145790
description	recommendedName: Connector enhancer of kinase suppressor of ras 2 shortName: Connector enhancer of KSR 2 alternativeName: CNK homolog protein 2 shortName: CNK2
displayName	UniProt:Q8WXI2 CNKSR2
geneName	CNKSR2 CNK2 KIAA0902 KSR2
identifier	Q8WXI2
isSequenceChanged	false
keyword	3D-structure Alternative splicing Coiled coil Cytoplasm Disease variant Intellectual disability Membrane Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CNKSR2
otherIdentifier	11736639_a_at 11759207_at 11760118_a_at 1554607_PM_at 1554607_at 17101990 206731_PM_at 206731_at 22866 229116_PM_at 229116_at 238832_PM_at 238832_at 34418_at 3971218 3971220 3971221 3971230 3971231 3971232 3971233 3971235 3971236 3971237 3971238 3971239 3971240 3971241 3971247 3971251 3971252 3971257 3971258 3971262 3971263 3971264 3971265 3971266 3971267 3971269 3971270 3971271 3971272 3971273 3971277 3971278 3971279 3971280 3971281 3971282 3971283 3971284 3971285 3971286 3971288 42822_at 53487_at 8166355 83196_at A_14_P100447 A_14_P104036 A_14_P112319 A_14_P112489 A_23_P153183 GE53573 GO:0005515 GO:0005737 GO:0005886 GO:0009966 GO:0014069 GO:0016020 GO:0019901 GO:0035556 GO:0042802 GO:0043025 GO:0043226 GO:0045211 GO:0070062 GO:0098978 GO:0099084 GO:0099147 GO:0099173 HMNXSV003001170 Hs.150353.0.A1_3p_at Hs.78406.1.A1_3p_at Hs2.100527.2.S1_3p_at ILMN_1795756 PH_hs_0035504 TC0X000097.hg g7662367_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5672632] CNKSR2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12720604] UCSC:Q8WXI2 CNKSR2 [ReferenceDNASequence:12105404] OMIM:300724 CNKSR2 [ReferenceDNASequence:12022215] NCBI Gene:22866 CNKSR2 [ReferenceDNASequence:11938122] Monarch:22866 CNKSR2 [ReferenceDNASequence:11852140] KEGG:hsa:22866 CNKSR2 [ReferenceDNASequence:11813537] HGNC:19701 CNKSR2 [ReferenceDNASequence:11433768] dbSNP Gene:22866 CNKSR2 [ReferenceDNASequence:11405133] CTD Gene:22866 CNKSR2 [ReferenceDNASequence:11394002] COSMIC - genes:KSR2 KSR2 [ReferenceDNASequence:11397133] COSMIC - genes:CNKSR2 CNKSR2 [ReferenceDNASequence:11308333] BioGPS Gene:22866 CNKSR2 [ReferenceDNASequence:ensembl:ENSG00000149970] ENSEMBL:ENSG00000149970 CNKSR2
referenceTranscript	[ReferenceRNASequence:12487547] RefSeq:NM_001168649.3 CNKSR2 [ReferenceRNASequence:12487549] RefSeq:NM_001168647.3 CNKSR2 [ReferenceRNASequence:12487548] RefSeq:NM_001168648.3 CNKSR2 [ReferenceRNASequence:12487546] RefSeq:NM_014927.4 CNKSR2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CNKR2_HUMAN B4DGR4 B7ZLJ1 B9EG83 E7ESA4 O94976 Q5JPK4 Q5JPN0 Q8WXI1
sequenceLength	1034
species	[Species:48887] Homo sapiens
stId	uniprot:Q8WXI2
url	http://purl.uniprot.org/uniprot/Q8WXI2

Referrals

(interactor)	[UndirectedInteraction:11234503] UniProt:P00533 <-> UniProt:Q8WXI2 (IntAct) [UndirectedInteraction:11181471] UniProt:Q96NW7 <-> UniProt:Q8WXI2 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5672632] CNKSR2 [cytosol]