Reactome | UniProt:Q8WVM7 STAG1

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UniProt:Q8WVM7 STAG1 Show undefined attributes

chain	chain:1-1258
checksum	FAF911998EC52179
comment	FUNCTION Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.SUBUNIT Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3) (PubMed:11076961, PubMed:22628566, PubMed:32409525). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3 (PubMed:11076961). Interacts directly with RAD21 in cohesin complex (By similarity). The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (PubMed:32409525).INTERACTION Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.ALTERNATIVE PRODUCTS Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SCC3 family.ONLINE INFORMATION Support to STAG1 syndrome patients and researchers
crossReference	[DatabaseIdentifier:12150752] PDB:5QSW [DatabaseIdentifier:12309142] RefSeq:NP_005853.2 [DatabaseIdentifier:12281090] Pharos - Targets:Q8WVM7 [DatabaseIdentifier:12238413] PRO:Q8WVM7 [DatabaseIdentifier:12150750] PDB:6QB5 [DatabaseIdentifier:12150754] PDB:5QSY [DatabaseIdentifier:12150751] PDB:5QSX [DatabaseIdentifier:12150745] PDB:6R7O [DatabaseIdentifier:11444482] ENSEMBL:ENSG00000118007 [DatabaseIdentifier:11530891] ENSEMBL:ENSP00000236698 [DatabaseIdentifier:11530892] ENSEMBL:ENSP00000372689 [DatabaseIdentifier:11653591] ENSEMBL:ENST00000236698 [DatabaseIdentifier:11653590] ENSEMBL:ENST00000383202 [DatabaseIdentifier:11783175] GeneCards:STAG1 [DatabaseIdentifier:11798784] GlyGen:Q8WVM7 [DatabaseIdentifier:11836284] HPA:ENSG00000118007-STAG1 [DatabaseIdentifier:12120757] OpenTargets:ENSG00000118007 [DatabaseIdentifier:12135818] Orphanet:STAG1 [DatabaseIdentifier:12150740] PDB:5QSS [DatabaseIdentifier:12150741] PDB:5QSV [DatabaseIdentifier:12150744] PDB:6RRK [DatabaseIdentifier:12150742] PDB:7W1M [DatabaseIdentifier:12150735] PDB:5QSP [DatabaseIdentifier:12150737] PDB:5QSR [DatabaseIdentifier:12150739] PDB:5QST [DatabaseIdentifier:12150738] PDB:5QSQ [DatabaseIdentifier:12150736] PDB:5QSO [DatabaseIdentifier:12150743] PDB:5QSU [DatabaseIdentifier:12150746] PDB:5QSN [DatabaseIdentifier:12150749] PDB:6WG3 [DatabaseIdentifier:12150747] PDB:5QSM [DatabaseIdentifier:12150748] PDB:6RRC [DatabaseIdentifier:12150753] PDB:5QSZ
databaseName	UniProt
dbId	64098
description	recommendedName: Cohesin subunit SA-1 alternativeName: SCC3 homolog 1 alternativeName: Stromal antigen 1
displayName	UniProt:Q8WVM7 STAG1
geneName	STAG1 SA1 SCC3
identifier	Q8WVM7
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Chromosome partition Disease variant Intellectual disability Isopeptide bond Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	STAG1
otherIdentifier	10274 11743276_s_at 11752130_a_at 11759484_s_at 1557502_3p_at 1557502_PM_at 1557502_at 16959531 202293_PM_at 202293_at 202294_PM_at 202294_at 232588_PM_at 232588_at 2696801 2696803 2696804 2696807 2696808 2696810 2696811 2696813 2696814 2696817 2696818 2696820 2696822 2696823 2696825 2696830 2696833 2696834 2696835 2696836 2696837 2696838 2696842 2696844 2696849 2696852 2696853 2696854 2696857 2696859 2696860 2696861 2696868 2696870 2696875 2696878 2696888 2696889 2696895 2696896 2696899 2696901 2696902 2696916 2696923 2696924 2696925 2696942 2696944 39246_at 50041_at 59787_s_at 63185_at 64351_at 64456_r_at 8090898 A_23_P357365 GE81569 GO:0000775 GO:0000785 GO:0003682 GO:0005515 GO:0005634 GO:0005654 GO:0005694 GO:0005829 GO:0005929 GO:0007010 GO:0007059 GO:0007062 GO:0008278 GO:0016363 GO:0016604 GO:0030892 GO:0034087 GO:0043226 GO:0051301 GO:0090307 GO:0097431 HMNXSV003013780 HMNXSV003027857 Hs.138263.0.A1_3p_at Hs.286148.0.S2_3p_at Hs.286148.0.S3_3p_at Hs2.311535.1.S1_3p_s_at ILMN_1792435 ILMN_2151048 PH_hs_0022560 TC03001812.hg Z75330_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-163016] STAG1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2466017] STAG1 [chromosome, centromeric region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1638773] STAG1 [chromosome] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2484793] STAG1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000118007] ENSEMBL:ENSG00000118007 STAG1 [ReferenceDNASequence:12721698] UCSC:Q8WVM7 STAG1 [ReferenceDNASequence:11310107] BioGPS Gene:10274 STAG1 [ReferenceDNASequence:11395730] COSMIC - genes:STAG1 PMEPA1 [ReferenceDNASequence:11406781] CTD Gene:10274 STAG1 [ReferenceDNASequence:11433949] dbSNP Gene:10274 STAG1 [ReferenceDNASequence:11814788] HGNC:11354 STAG1 [ReferenceDNASequence:11853820] KEGG:hsa:10274 STAG1 [ReferenceDNASequence:11939896] Monarch:10274 STAG1 [ReferenceDNASequence:12023989] NCBI Gene:10274 STAG1 [ReferenceDNASequence:12106529] OMIM:604358 STAG1
referenceTranscript	[ReferenceRNASequence:12491255] RefSeq:NM_005862.3 STAG1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	STAG1_HUMAN O00539 Q6P275
sequenceLength	1258
species	[Species:48887] Homo sapiens
stId	uniprot:Q8WVM7
url	http://purl.uniprot.org/uniprot/Q8WVM7

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