UniProt:Q8WV44 TRIM41

chain
  • chain:1-630
checksum 8E704CBEAB928BF5
comment
  • FUNCTION E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with PRKCA (PubMed:17893151). Interacts with NOD2 (PubMed:27812135). Interacts with TRIM17; this interaction prevents TRIM41 activity on ZSCAN2 (By similarity).INTERACTION Expressed in multiple tissues with the highest levels in heart and skeletal muscle.INDUCTION Down-regulated by muramyl-dipeptide and lipopolysaccharide.PTM Auto-ubiquitinated.SIMILARITY Belongs to the TRIM/RBCC family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 154979
description
  • recommendedName: fullName evidence="22"E3 ubiquitin-protein ligase TRIM41 ecNumber evidence="11 12 13"2.3.2.27 alternativeName: fullName evidence="20"RING finger-interacting protein with C kinase shortName evidence="20"RINCK alternativeName: Tripartite motif-containing protein 41
displayName UniProt:Q8WV44 TRIM41
geneName
  • TRIM41
  • RINCK
identifier Q8WV44
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Coiled coil
  • Cytoplasm
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transferase
  • Ubl conjugation
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • TRIM41
otherIdentifier
  • 11726971_a_at
  • 11749621_a_at
  • 11749622_x_at
  • 11756426_x_at
  • 16993611
  • 226445_PM_s_at
  • 226445_s_at
  • 2845044
  • 2845045
  • 2845046
  • 2845047
  • 2845048
  • 2845049
  • 2845050
  • 2845051
  • 2845052
  • 2845053
  • 2845054
  • 2845055
  • 2845056
  • 2845057
  • 2845058
  • 2845059
  • 2845060
  • 2845061
  • 2845062
  • 2845063
  • 2845064
  • 2845065
  • 2845066
  • 2845067
  • 2845069
  • 55604_at
  • 77794_at
  • 79801_at
  • 8110649
  • 90933
  • A_14_P131629
  • A_23_P167521
  • A_24_P252020
  • A_33_P3216316
  • A_33_P3354434
  • GE56759
  • GO:0001650
  • GO:0002376
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0006513
  • GO:0008270
  • GO:0009967
  • GO:0016567
  • GO:0016740
  • GO:0042802
  • GO:0045087
  • GO:0046872
  • GO:0051607
  • GO:0060340
  • GO:0061630
  • GO:0071222
  • GO:0071225
  • GO:0098542
  • GO:0140096
  • HMNXSV003049057
  • Hs.332612.0.A1_3p_s_at
  • ILMN_1729495
  • ILMN_1813027
  • PH_hs_0016727
  • TC05001083.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TRI41_HUMAN
  • B3KNJ6
  • D3DWR9
  • Q5BKT0
  • Q7L484
  • Q96Q10
  • Q9BSL8
sequenceLength 630
species [Species:48887] Homo sapiens
stId uniprot:Q8WV44
url http://purl.uniprot.org/uniprot/Q8WV44
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