Reactome | UniProt:Q8WTT0 CLEC4C

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UniProt:Q8WTT0 CLEC4C Show undefined attributes

chain	chain:1-213
checksum	5DC82C95BE2378C1
comment	FUNCTION Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).SUBUNIT Homodimer.INTERACTION Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF.ONLINE INFORMATION BDCA-2
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11445301] ENSEMBL:ENSG00000198178 [DatabaseIdentifier:11532099] ENSEMBL:ENSP00000346648 [DatabaseIdentifier:11532096] ENSEMBL:ENSP00000353500 [DatabaseIdentifier:11532097] ENSEMBL:ENSP00000440428 [DatabaseIdentifier:11532098] ENSEMBL:ENSP00000445338 [DatabaseIdentifier:11654795] ENSEMBL:ENST00000354629 [DatabaseIdentifier:11654797] ENSEMBL:ENST00000540085 [DatabaseIdentifier:11654796] ENSEMBL:ENST00000542353 [DatabaseIdentifier:11654798] ENSEMBL:ENST00000360345 [DatabaseIdentifier:11780920] Guide to Pharmacology - Targets:3135 [DatabaseIdentifier:11783955] GeneCards:CLEC4C [DatabaseIdentifier:11799484] GlyGen:Q8WTT0 [DatabaseIdentifier:11831379] HMDB Protein:HMDBP07589 [DatabaseIdentifier:11837058] HPA:ENSG00000198178-CLEC4C [DatabaseIdentifier:12121546] OpenTargets:ENSG00000198178 [DatabaseIdentifier:12154766] PDB:3WBR [DatabaseIdentifier:12154764] PDB:3WBP [DatabaseIdentifier:12154768] PDB:4ZET [DatabaseIdentifier:12154765] PDB:3WBQ [DatabaseIdentifier:12154767] PDB:4ZES [DatabaseIdentifier:12239418] PRO:Q8WTT0 [DatabaseIdentifier:12281871] Pharos - Targets:Q8WTT0 [DatabaseIdentifier:12310938] RefSeq:XP_054227313.1 [DatabaseIdentifier:12310939] RefSeq:NP_987099.1 [DatabaseIdentifier:12310935] RefSeq:XP_054227314.1 [DatabaseIdentifier:12310936] RefSeq:NP_001358319.1 [DatabaseIdentifier:12310934] RefSeq:NP_569708.1 [DatabaseIdentifier:12310937] RefSeq:XP_054227312.1 [DatabaseIdentifier:12310940] RefSeq:XP_024304641.1
databaseName	UniProt
dbId	224250
description	recommendedName: C-type lectin domain family 4 member C alternativeName: Blood dendritic cell antigen 2 shortName: BDCA-2 alternativeName: C-type lectin superfamily member 7 alternativeName: Dendritic lectin cdAntigenNameCD303/cdAntigenName
displayName	UniProt:Q8WTT0 CLEC4C
geneName	CLEC4C BDCA2 CLECSF11 CLECSF7 DLEC HECL UNQ9361/PRO34150
identifier	Q8WTT0
isSequenceChanged	false
keyword	3D-structure Adaptive immunity Alternative splicing Calcium Cell membrane Disulfide bond Glycoprotein Immunity Innate immunity Lectin Membrane Metal-binding Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	CLEC4C
otherIdentifier	11736954_a_at 11738898_a_at 11759227_at 1552552_PM_s_at 1552552_s_at 1555687_PM_a_at 1555687_a_at 16760825 170482 3442786 3442787 3442788 3442789 3442790 3442791 3442793 3442794 3442795 3442796 3442797 3442798 3442799 3442800 3884063 66038_at 7960832 A_23_P2616 GE559150 GO:0002250 GO:0002376 GO:0005515 GO:0005886 GO:0009897 GO:0016020 GO:0030246 GO:0030667 GO:0038187 GO:0045087 GO:0046872 GO:0061760 GO:0070821 GO:0098542 GO:0101003 HMNXSV003044009 Hs2.351812.1.S1_3p_s_at ILMN_1665457 ILMN_1682259 PH_hs_0017013 TC12001165.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801022] CLEC4C [secretory granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2130705] CLEC4C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800186] CLEC4C [tertiary granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800915] CLEC4C [ficolin-1-rich granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000198178] ENSEMBL:ENSG00000198178 CLEC4C [ReferenceDNASequence:12722229] UCSC:Q8WTT0 CLEC4C [ReferenceDNASequence:11310974] BioGPS Gene:170482 CLEC4C [ReferenceDNASequence:11397390] COSMIC - genes:CLEC4C CLEC4C [ReferenceDNASequence:11407730] CTD Gene:170482 CLEC4C [ReferenceDNASequence:11434068] dbSNP Gene:170482 CLEC4C [ReferenceDNASequence:11815579] HGNC:13258 CLEC4C [ReferenceDNASequence:11854653] KEGG:hsa:170482 CLEC4C [ReferenceDNASequence:11940763] Monarch:170482 CLEC4C [ReferenceDNASequence:12024856] NCBI Gene:170482 CLEC4C [ReferenceDNASequence:12107232] OMIM:606677 CLEC4C
referenceTranscript	[ReferenceRNASequence:12493013] RefSeq:NM_001371390.1 CLEC4C [ReferenceRNASequence:12493014] RefSeq:XM_054371338.1 CLEC4C [ReferenceRNASequence:12493012] RefSeq:XM_054371339.1 CLEC4C [ReferenceRNASequence:12493016] RefSeq:XM_054371337.1 CLEC4C [ReferenceRNASequence:12493018] RefSeq:NM_203503.2 CLEC4C [ReferenceRNASequence:12493015] RefSeq:NM_130441.3 CLEC4C [ReferenceRNASequence:12493017] RefSeq:XM_024448873.2 CLEC4C
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CLC4C_HUMAN D3DUU3 Q3T1C3 Q6UXS8 Q8WXX8
sequenceLength	213
species	[Species:48887] Homo sapiens
stId	uniprot:Q8WTT0
url	http://purl.uniprot.org/uniprot/Q8WTT0

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