Reactome | UniProt:Q8TCU6 PREX1

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UniProt:Q8TCU6 PREX1 Show undefined attributes

chain	chain:1-1659
checksum	159419355ED0F00F
comment	FUNCTION Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.SUBUNIT Interacts preferentially with RAC2. Interacts with RAC1. Interacts with AUTS2.INTERACTION Mainly cytosolic. Some amount is apparently associated to the plasma membrane.ALTERNATIVE PRODUCTS Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12292305] Pharos - Targets:Q8TCU6 [DatabaseIdentifier:12254530] PRO:Q8TCU6 [DatabaseIdentifier:12222479] PDB:6VSK [DatabaseIdentifier:12222481] PDB:5D3W [DatabaseIdentifier:12165539] PDB:4YON [DatabaseIdentifier:12222484] PDB:5D27 [DatabaseIdentifier:12222483] PDB:5D3Y [DatabaseIdentifier:12222482] PDB:5D3V [DatabaseIdentifier:12222480] PDB:7RX9 [DatabaseIdentifier:12222488] PDB:3QIK [DatabaseIdentifier:12222485] PDB:5D3X [DatabaseIdentifier:12166199] PDB:6PCV [DatabaseIdentifier:12211739] PDB:5FI1 [DatabaseIdentifier:12222487] PDB:7SYF [DatabaseIdentifier:12165540] PDB:5FI0 [DatabaseIdentifier:12222486] PDB:8TUA [DatabaseIdentifier:12132122] OpenTargets:ENSG00000124126 [DatabaseIdentifier:11847445] HPA:ENSG00000124126-PREX1 [DatabaseIdentifier:11831531] HMDB Protein:HMDBP07343 [DatabaseIdentifier:11810418] GlyGen:Q8TCU6 [DatabaseIdentifier:11794472] GeneCards:PREX1 [DatabaseIdentifier:11677074] ENSEMBL:ENST00000371941 [DatabaseIdentifier:11554375] ENSEMBL:ENSP00000361009 [DatabaseIdentifier:11461194] ENSEMBL:ENSG00000124126
databaseName	UniProt
dbId	411856
description	recommendedName: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein shortName: P-Rex1 shortName: PtdIns(3,4,5)-dependent Rac exchanger 1
displayName	UniProt:Q8TCU6 PREX1
geneName	PREX1 KIAA1415
identifier	Q8TCU6
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Cytoplasm Direct protein sequencing Guanine-nucleotide releasing factor Membrane Phosphoprotein Proteomics identification Reference proteome Repeat
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PREX1
otherIdentifier	11716848_a_at 11716849_s_at 16920047 224909_PM_s_at 224909_s_at 224925_PM_at 224925_at 3908632 3908633 3908634 3908635 3908636 3908637 3908638 3908640 3908643 3908644 3908645 3908646 3908647 3908648 3908649 3908650 3908652 3908654 3908656 3908657 3908658 3908659 3908660 3908662 3908663 3908664 3908665 3908666 3908667 3908668 3908669 3908670 3908671 3908672 3908673 3908675 3908676 3908677 3908678 3908679 3908680 3908683 3908684 3908685 3908691 3908692 3908693 3908694 3908697 3908698 3908700 3908701 3908706 3908707 3908729 3908730 56420_at 57580 8066848 GE53958 GO:0002376 GO:0005085 GO:0005096 GO:0005515 GO:0005543 GO:0005737 GO:0005829 GO:0005886 GO:0006801 GO:0007186 GO:0016020 GO:0019899 GO:0030041 GO:0030154 GO:0030217 GO:0030291 GO:0030335 GO:0030426 GO:0030593 GO:0030833 GO:0032007 GO:0035556 GO:0042119 GO:0043198 GO:0045321 GO:0045785 GO:0048471 GO:0048870 GO:0050773 GO:0051056 GO:0072593 GO:0098772 GO:1900026 HMNXSV003055293 Hs.109315.1.S1_3p_a_at Hs.109315.1.S2_3p_at ILMN_1777342 PH_hs_0025589 TC20000920.hg p33805
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8863083] PREX1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12678890] UCSC:Q8TCU6 PREX1 [ReferenceDNASequence:12116514] OMIM:606905 PREX1 [ReferenceDNASequence:12039538] NCBI Gene:57580 PREX1 [ReferenceDNASequence:11955445] Monarch:57580 PREX1 [ReferenceDNASequence:11868028] KEGG:hsa:57580 PREX1 [ReferenceDNASequence:11826169] HGNC:32594 PREX1 [ReferenceDNASequence:11427763] dbSNP Gene:57580 PREX1 [ReferenceDNASequence:11423233] CTD Gene:57580 PREX1 [ReferenceDNASequence:11392025] COSMIC - genes:PREX1 PREX1 [ReferenceDNASequence:11325656] BioGPS Gene:57580 PREX1 [ReferenceDNASequence:ensembl:ENSG00000124126] ENSEMBL:ENSG00000124126 PREX1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PREX1_HUMAN E1P5X9 Q5JS95 Q5JS96 Q69YL2 Q7Z2L9 Q9BQH0 Q9BX55 Q9H4Q6 Q9P2D2 Q9UGQ4
sequenceLength	1659
species	[Species:48887] Homo sapiens
stId	uniprot:Q8TCU6
url	http://purl.uniprot.org/uniprot/Q8TCU6

Referrals

(interactor)	[UndirectedInteraction:11240917] UniProt:P08581 <-> UniProt:Q8TCU6 (IntAct) [UndirectedInteraction:11183251] UniProt:P31750 <-> UniProt:Q8TCU6 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8863083] PREX1 [cytosol]