UniProt:Q8TAT6 NPLOC4

chain
  • initiator methionine:1
  • chain:2-608
checksum 6ED6A0145F15C01D
comment
  • FUNCTION The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).PATHWAY Protein degradation; proteasomal ubiquitin-dependent pathway.SUBUNIT Heterodimer with UFD1 (PubMed:11574150, PubMed:26471729). The heterodimer binds ubiquitinated proteins (By similarity). The heterodimer binds to VCP and inhibits Golgi membrane fusion (PubMed:11574150, PubMed:26471729). Interacts with ZFAND2B; probably through VCP (PubMed:24160817).INTERACTION Associated with the endoplasmic reticulum and nuclear.ALTERNATIVE PRODUCTS Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.DOMAIN Binds ubiquitinated proteins via its RanBP2-type zinc finger.MISCELLANEOUS May be due to an intron retention.SIMILARITY Belongs to the NPL4 family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 151256
description
  • recommendedName: Nuclear protein localization protein 4 homolog shortName: Protein NPL4
displayName UniProt:Q8TAT6 NPLOC4
geneName
  • NPLOC4
  • KIAA1499
  • NPL4
identifier Q8TAT6
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Chaperone
  • Cytoplasm
  • Direct protein sequencing
  • Endoplasmic reticulum
  • Metal-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • NPLOC4
otherIdentifier
  • 11733893_a_at
  • 11755047_a_at
  • 11755406_x_at
  • 11761364_a_at
  • 16849882
  • 217796_PM_s_at
  • 217796_s_at
  • 3774030
  • 3774031
  • 3774032
  • 3774033
  • 3774034
  • 3774035
  • 3774036
  • 3774037
  • 3774038
  • 3774039
  • 3774040
  • 3774041
  • 3774042
  • 3774043
  • 3774045
  • 3774055
  • 3774056
  • 3774059
  • 3774060
  • 3774063
  • 3774064
  • 3774066
  • 3774073
  • 3774074
  • 3774075
  • 3774077
  • 3774078
  • 3774079
  • 3774080
  • 3774082
  • 3774084
  • 3774085
  • 3774087
  • 3774090
  • 3774095
  • 55666
  • 61951_at
  • 65788_at
  • 8019211
  • 90976_at
  • A_23_P72044
  • A_33_P3238966
  • GE55586
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005783
  • GO:0005829
  • GO:0006511
  • GO:0006886
  • GO:0007030
  • GO:0008270
  • GO:0030163
  • GO:0030970
  • GO:0031625
  • GO:0032480
  • GO:0034098
  • GO:0036435
  • GO:0036501
  • GO:0036503
  • GO:0039536
  • GO:0042175
  • GO:0043130
  • GO:0043161
  • GO:0044877
  • GO:0046872
  • GO:0051117
  • GO:0070530
  • HMNXSV003026832
  • ILMN_1807600
  • PH_hs_0023960
  • TC17001954.hg
  • g8923608_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NPL4_HUMAN
  • Q8N3J1
  • Q9H8V2
  • Q9H964
  • Q9NWR5
  • Q9P229
sequenceLength 608
species [Species:48887] Homo sapiens
stId uniprot:Q8TAT6
url http://purl.uniprot.org/uniprot/Q8TAT6
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