UniProt:Q8TAD8 SNIP1

chain
  • chain:1-396
checksum B183F83EC3184676
comment
  • FUNCTION Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.SUBUNIT Component of activated spliceosome complexes (PubMed:29360106). Component of the minor spliceosome, which splices U12-type introns (PubMed:33509932). Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.INTERACTION Ubiquitous, with highest expression in heart and skeletal muscle.PTM Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.DISEASE The disease is caused by variants affecting the gene represented in this entry.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 154172
description
  • recommendedName: Smad nuclear-interacting protein 1 alternativeName: FHA domain-containing protein SNIP1
displayName UniProt:Q8TAD8 SNIP1
geneName
  • SNIP1
identifier Q8TAD8
isSequenceChanged false
keyword
  • 3D-structure
  • Coiled coil
  • Disease variant
  • Epilepsy
  • Isopeptide bond
  • mRNA processing
  • mRNA splicing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • RNA-mediated gene silencing
  • Spliceosome
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SNIP1
otherIdentifier
  • 11743761_a_at
  • 11743762_at
  • 11751150_a_at
  • 11751310_a_at
  • 16685374
  • 219409_PM_at
  • 219409_at
  • 235837_PM_at
  • 235837_at
  • 2407162
  • 2407164
  • 2407165
  • 2407166
  • 2407167
  • 2407168
  • 2407169
  • 2407170
  • 2407174
  • 2407175
  • 2407180
  • 2407181
  • 2407182
  • 2407183
  • 2407184
  • 49855_at
  • 53646_at
  • 60943_at
  • 7915008
  • 79753
  • A_24_P276531
  • GE62387
  • GE825497
  • GO:0000398
  • GO:0003723
  • GO:0003729
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0005686
  • GO:0005829
  • GO:0006355
  • GO:0006397
  • GO:0008380
  • GO:0010468
  • GO:0016071
  • GO:0031047
  • GO:0035196
  • GO:0043124
  • GO:0045944
  • GO:0065003
  • GO:0071005
  • GO:0140416
  • GO:1903241
  • HMNXSV003043225
  • Hs.47232.0.A1_3p_at
  • ILMN_1651278
  • PH_hs_0005560
  • TC01002518.hg
  • g13375986_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SNIP1_HUMAN
  • Q96SP9
  • Q9H9T7
sequenceLength 396
species [Species:48887] Homo sapiens
stId uniprot:Q8TAD8
url http://purl.uniprot.org/uniprot/Q8TAD8

Referrals

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