Reactome | UniProt:Q8T4F7 ena

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UniProt:Q8T4F7 ena Show undefined attributes

chain	chain:1-980
checksum	7B084A0AEC098297
comment	FUNCTION Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.SUBUNIT Interacts with Abl and Src SH3 domains. Binds, in vitro and in vivo, the cytoplasmic domain of robo. Interacts with Zyx102EF and chic.INTERACTION Expressed at the leading edge of lamellipodia. Colocalizes with chic at the periphery of cells.ALTERNATIVE PRODUCTS Expressed in axons of the embryonic nervous system.DOMAIN The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.PTM Tyrosine phosphorylated on multiple sites by Abl kinase. In vitro, phosphorylation on specific tyrosine residues inhibits interaction with Abl and Src SH3 domains.SIMILARITY Belongs to the Ena/VASP family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12318519] RefSeq:NP_001014536.1 [DatabaseIdentifier:12318522] RefSeq:NP_725857.1 [DatabaseIdentifier:12318523] RefSeq:NP_725858.1 [DatabaseIdentifier:12318521] RefSeq:NP_725859.2 [DatabaseIdentifier:12318520] RefSeq:NP_001014537.1 [DatabaseIdentifier:12318518] RefSeq:NP_001137709.1 [DatabaseIdentifier:12243651] PRO:Q8T4F7 [DatabaseIdentifier:11773469] FlyBase:FBgn0000578 [DatabaseIdentifier:11660231] ENSEMBL:FBtr0114623 [DatabaseIdentifier:11537532] ENSEMBL:FBpp0113115 [DatabaseIdentifier:11448974] ENSEMBL:FBgn0000578
databaseName	UniProt
dbId	228292
description	recommendedName: Protein enabled
displayName	UniProt:Q8T4F7 ena
geneName	ena enb CG15112
identifier	Q8T4F7
isSequenceChanged	false
keyword	Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Phosphoprotein Reference proteome SH3-binding
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	ena
otherIdentifier	154185_at 1627191_a_at 37201 GO:0003382 GO:0003779 GO:0005515 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005925 GO:0007015 GO:0007298 GO:0007300 GO:0007390 GO:0007391 GO:0007396 GO:0007409 GO:0007411 GO:0008092 GO:0008154 GO:0008258 GO:0010591 GO:0017124 GO:0030027 GO:0030036 GO:0030054 GO:0030335 GO:0030424 GO:0030425 GO:0031252 GO:0031346 GO:0032433 GO:0032956 GO:0035262 GO:0042995 GO:0043226 GO:0045886 GO:0046847 GO:0046907 GO:0048749 GO:0048813 GO:0048856 GO:0048870 GO:0051489 GO:0051491 GO:0060288 GO:0071212 GO:1990255
physicalEntity	[EntityWithAccessionedSequence:R-DME-434965] ENA [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-446323] ena [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-426406] ena [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-426403] ena [cytosol] - Drosophila melanogaster
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12672422] UCSC:Q8T4F7 ena [ReferenceDNASequence:12028414] NCBI Gene:37201 ena [ReferenceDNASequence:11944321] Monarch:37201 ena [ReferenceDNASequence:11858007] KEGG:dme:Dmel_CG15112 ena [ReferenceDNASequence:11411493] CTD Gene:37201 ena [ReferenceDNASequence:11314532] BioGPS Gene:37201 ena
referenceTranscript	[ReferenceRNASequence:12500529] RefSeq:NM_166331.3 ena [ReferenceRNASequence:12500527] RefSeq:NM_001144237.2 ena [ReferenceRNASequence:12500532] RefSeq:NM_166329.2 ena [ReferenceRNASequence:12500528] RefSeq:NM_166330.2 ena [ReferenceRNASequence:12500530] RefSeq:NM_001014536.2 ena [ReferenceRNASequence:12500531] RefSeq:NM_001014537.3 ena
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ENA_DROME A4UZP3 B7YZL0 Q24035 Q86NN6 Q8MMB3 Q9V8R3
sequenceLength	980
species	[Species:56210] Drosophila melanogaster
stId	uniprot:Q8T4F7
url	http://purl.uniprot.org/uniprot/Q8T4F7

Referrals

(interactor)	[UndirectedInteraction:11135047] UniProt:Q8T4F7 <-> UniProt:P25843 (IntAct) [UndirectedInteraction:11135043] UniProt:Q8T4F7 <-> UniProt:P00522 (IntAct) [UndirectedInteraction:11135041] UniProt:Q8T4F7 <-> UniProt:P16621 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-DME-434965] ENA [cytosol] [EntityWithAccessionedSequence:R-DME-446323] ena [cytosol] [EntityWithAccessionedSequence:R-DME-426406] ena [cytosol] [EntityWithAccessionedSequence:R-DME-426403] ena [cytosol]