Reactome | UniProt:Q8NI32 LYPD6B

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UniProt:Q8NI32 LYPD6B Show undefined attributes

chain	signal peptide:1-39 chain:40-164 propeptide:165-183
checksum	817D3D181568C5A2
comment	FUNCTION Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:26586467, PubMed:34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed:26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed:34631692).SUBCELLULAR LOCATION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12370242] RefSeq:XP_047299367.1 [DatabaseIdentifier:12370228] RefSeq:XP_054196535.1 [DatabaseIdentifier:12370230] RefSeq:XP_054196537.1 [DatabaseIdentifier:12370227] RefSeq:XP_016858854.1 [DatabaseIdentifier:12370238] RefSeq:XP_011508925.1 [DatabaseIdentifier:11473159] ENSEMBL:ENSG00000150556 [DatabaseIdentifier:11571171] ENSEMBL:ENSP00000387077 [DatabaseIdentifier:11571172] ENSEMBL:ENSP00000386479 [DatabaseIdentifier:11571170] ENSEMBL:ENSP00000386650 [DatabaseIdentifier:11693869] ENSEMBL:ENST00000409876 [DatabaseIdentifier:11693870] ENSEMBL:ENST00000409029 [DatabaseIdentifier:11693871] ENSEMBL:ENST00000409642 [DatabaseIdentifier:11788263] GeneCards:LYPD6B [DatabaseIdentifier:11803809] GlyGen:Q8NI32 [DatabaseIdentifier:11841319] HPA:ENSG00000150556-LYPD6B [DatabaseIdentifier:12125881] OpenTargets:ENSG00000150556 [DatabaseIdentifier:12183247] PDB:6ZSO [DatabaseIdentifier:12265794] PRO:Q8NI32 [DatabaseIdentifier:12286155] Pharos - Targets:Q8NI32 [DatabaseIdentifier:12370234] RefSeq:XP_054196545.1 [DatabaseIdentifier:12370235] RefSeq:XP_054196533.1 [DatabaseIdentifier:12370236] RefSeq:XP_054196544.1 [DatabaseIdentifier:12370223] RefSeq:NP_001303935.1 [DatabaseIdentifier:12370226] RefSeq:NP_808879.2 [DatabaseIdentifier:12370225] RefSeq:XP_054196536.1 [DatabaseIdentifier:12370229] RefSeq:XP_016858855.1 [DatabaseIdentifier:12370240] RefSeq:XP_047299369.1 [DatabaseIdentifier:12370239] RefSeq:XP_047299368.1 [DatabaseIdentifier:12370220] RefSeq:NP_001303933.1 [DatabaseIdentifier:12370241] RefSeq:XP_047299366.1 [DatabaseIdentifier:12370232] RefSeq:XP_054196542.1 [DatabaseIdentifier:12370237] RefSeq:XP_006712344.1 [DatabaseIdentifier:12370219] RefSeq:NP_001303934.1 [DatabaseIdentifier:12370224] RefSeq:XP_016858853.1 [DatabaseIdentifier:12370233] RefSeq:XP_054196534.1 [DatabaseIdentifier:12370221] RefSeq:NP_001303932.1 [DatabaseIdentifier:12370231] RefSeq:XP_054196543.1 [DatabaseIdentifier:12370222] RefSeq:NP_001303931.1
databaseName	UniProt
dbId	235483
description	recommendedName: Ly6/PLAUR domain-containing protein 6B
displayName	UniProt:Q8NI32 LYPD6B
geneName	LYPD6B
identifier	Q8NI32
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Proteomics identification Reference proteome Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LYPD6B
otherIdentifier	11744596_a_at 130576 228360_PM_at 228360_at 2509989 2509998 2510005 2510006 2510013 2510014 2510015 2510016 2510017 2510018 2510020 2510022 2510023 2510024 2510025 2510026 2510028 2510030 2510031 2510032 2510033 45695_at 8045664 90700_at A_14_P102145 A_14_P106969 A_14_P126732 A_23_P79302 GE503449 GO:0005576 GO:0005886 GO:0016020 GO:0030548 GO:0098552 GO:0098772 HMNXSV003050662 Hs.50831.0.A1_3p_at ILMN_1693119 PH_hs_0024010
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8940711] GPI-LYPD6B [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8941040] cleaved GPI-LYPD6B [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000150556] ENSEMBL:ENSG00000150556 LYPD6B [ReferenceDNASequence:12738691] UCSC:Q8NI32 LYPD6B [ReferenceDNASequence:11338309] BioGPS Gene:130576 LYPD6B [ReferenceDNASequence:11399504] COSMIC - genes:LYPD6B LYPD6B [ReferenceDNASequence:11414431] CTD Gene:130576 LYPD6B [ReferenceDNASequence:11436516] dbSNP Gene:130576 LYPD6B [ReferenceDNASequence:11819914] HGNC:27018 LYPD6B [ReferenceDNASequence:11879238] KEGG:hsa:130576 LYPD6B [ReferenceDNASequence:11968098] Monarch:130576 LYPD6B [ReferenceDNASequence:12052191] NCBI Gene:130576 LYPD6B
referenceTranscript	[ReferenceRNASequence:12552042] RefSeq:XM_054340558.1 LYPD6B [ReferenceRNASequence:12552053] RefSeq:NM_177964.4 LYPD6B [ReferenceRNASequence:12552035] RefSeq:NM_001317003.2 LYPD6B [ReferenceRNASequence:12552046] RefSeq:XM_054340561.1 LYPD6B [ReferenceRNASequence:12552040] RefSeq:XM_054340559.1 LYPD6B [ReferenceRNASequence:12552047] RefSeq:XM_054340560.1 LYPD6B [ReferenceRNASequence:12552032] RefSeq:XM_047443412.1 LYPD6B [ReferenceRNASequence:12552049] RefSeq:XM_017003366.2 LYPD6B [ReferenceRNASequence:12552039] RefSeq:XM_017003364.2 LYPD6B [ReferenceRNASequence:12552030] RefSeq:XM_047443413.1 LYPD6B [ReferenceRNASequence:12552052] RefSeq:XM_054340570.1 LYPD6B [ReferenceRNASequence:12552033] RefSeq:XM_047443411.1 LYPD6B [ReferenceRNASequence:12552036] RefSeq:NM_001317004.1 LYPD6B [ReferenceRNASequence:12552041] RefSeq:XM_011510623.3 LYPD6B [ReferenceRNASequence:12552044] RefSeq:XM_054340568.1 LYPD6B [ReferenceRNASequence:12552045] RefSeq:XM_054340562.1 LYPD6B [ReferenceRNASequence:12552038] RefSeq:XM_017003365.2 LYPD6B [ReferenceRNASequence:12552034] RefSeq:XM_047443410.1 LYPD6B [ReferenceRNASequence:12552048] RefSeq:XM_054340567.1 LYPD6B [ReferenceRNASequence:12552043] RefSeq:XM_054340569.1 LYPD6B [ReferenceRNASequence:12552037] RefSeq:NM_001317002.2 LYPD6B [ReferenceRNASequence:12552050] RefSeq:NM_001317005.2 LYPD6B [ReferenceRNASequence:12552051] RefSeq:NM_001317006.1 LYPD6B [ReferenceRNASequence:12552031] RefSeq:XM_006712281.5 LYPD6B
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LPD6B_HUMAN D3DP90 Q53TK0 Q7Z747 Q8IXK7
sequenceLength	183
species	[Species:48887] Homo sapiens
stId	uniprot:Q8NI32
url	http://purl.uniprot.org/uniprot/Q8NI32

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8940711] GPI-LYPD6B [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8941040] cleaved GPI-LYPD6B [extracellular region]
(referenceSequence)	[GroupModifiedResidue:8940800] L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1?)) at 164 [GroupModifiedResidue:8941037] L-serine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 164

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