UniProt:Q8NHH9 ATL2

chain
  • chain:1-583
checksum 885738C43996DEBF
comment
  • FUNCTION Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:22065636, PubMed:27619977, PubMed:34817557). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION With its alternative C-terminus disrupting the autoinhibitory domain, this brain-specific isoform is probably more active at fusing ER membranes.SUBUNIT Monomeric and homodimeric. The homodimer, transiently formed by two molecules on opposing membranes, is the active form mediating ER membrane fusion (PubMed:22065636). Interacts with REEP5 and RTN3; these proteins are involved in endoplasmic reticulum tubular network organization (PubMed:19665976). Interacts with ZFYVE27; both proteins are involved in endoplasmic reticulum tubular network organization (PubMed:23969831).INTERACTION Localizes at endoplasmic reticulum (ER) three-way tubular junctions (PubMed:27619977).ALTERNATIVE PRODUCTS Expressed in peripheral tissues (at protein level).DOMAIN The GB1/RHD3-type G domain mediates GTP-binding and hydrolysis as well as homodimerization.DOMAIN The two three-helix bundle (3HB) regions in the homodimer are loosely associated initially, but they tighten upon GTP hydrolysis, facilitating the fusion of membranes.DOMAIN The C-terminal autoinhibitory domain negatively regulates the GTPase-dependent fusogenic activity without affecting GTP-binding.SIMILARITY Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 219643
description
  • recommendedName: fullName evidence="16"Atlastin-2 shortName evidence="17"ATL-2 ecNumber evidence="7"3.6.5.- alternativeName: fullName evidence="21"ADP-ribosylation factor-like protein 6-interacting protein 2
displayName UniProt:Q8NHH9 ATL2
geneName
  • ATL2
  • ARL6IP2
identifier Q8NHH9
isSequenceChanged false
keyword
  • Alternative splicing
  • Coiled coil
  • Endoplasmic reticulum
  • GTP-binding
  • Hydrolase
  • Magnesium
  • Membrane
  • Metal-binding
  • Methylation
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • ATL2
otherIdentifier
  • 11722058_s_at
  • 11748040_a_at
  • 11751006_a_at
  • 1553603_PM_s_at
  • 1553603_s_at
  • 16896579
  • 217580_3p_x_at
  • 217580_PM_x_at
  • 217580_x_at
  • 222700_PM_at
  • 222700_at
  • 235848_PM_x_at
  • 235848_x_at
  • 237968_PM_at
  • 237968_at
  • 2548777
  • 2548778
  • 2548779
  • 2548780
  • 2548781
  • 2548782
  • 2548783
  • 2548784
  • 2548785
  • 2548786
  • 2548789
  • 2548791
  • 2548793
  • 2548794
  • 2548796
  • 2548797
  • 2548798
  • 2548801
  • 2548802
  • 2548803
  • 2548815
  • 2548816
  • 2548817
  • 2548818
  • 2548819
  • 2548824
  • 2548825
  • 2548826
  • 2548827
  • 44662_at
  • 61133_r_at
  • 64225
  • 8051589
  • 82645_at
  • A_23_P209619
  • A_23_P415015
  • A_33_P3394040
  • GE672602
  • GE82685
  • GE87622
  • GO:0000166
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005783
  • GO:0005789
  • GO:0007029
  • GO:0007030
  • GO:0016020
  • GO:0016320
  • GO:0016787
  • GO:0046872
  • GO:0051260
  • GO:0061024
  • GO:0065003
  • GO:0098826
  • GO:0098827
  • GO:0140523
  • GO:1990809
  • HMNXSV003050512
  • Hs.150551.0.A1_3p_at
  • Hs.150551.0.A1_3p_x_at
  • Hs.167253.0.A1_3p_at
  • Hs.31236.0.S2_3p_at
  • Hs.53031.0.A1_3p_at
  • Hs2.27099.1.S1_3p_s_at
  • ILMN_1716384
  • PH_hs_0024157
  • TC02001753.hg
  • TC02004168.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ATLA2_HUMAN
  • B7Z1X2
  • B7Z7X8
  • Q4ZG30
  • Q7Z630
  • Q8NHH8
  • Q9H5M7
sequenceLength 583
species [Species:48887] Homo sapiens
stId uniprot:Q8NHH9
url http://purl.uniprot.org/uniprot/Q8NHH9
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