Reactome | UniProt:Q8NEM7 SUPT20H

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UniProt:Q8NEM7 SUPT20H Show undefined attributes

chain	chain:1-779
checksum	4CD7DFD8719F621C
comment	FUNCTION Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.SUBUNIT Interacts with MAPK14. Interacts with ATG9A.INTERACTION Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.SIMILARITY Belongs to the SPT20 family.SEQUENCE CAUTION Intron retention.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11474343] ENSEMBL:ENSG00000102710 [DatabaseIdentifier:11573040] ENSEMBL:ENSP00000218894 [DatabaseIdentifier:11573044] ENSEMBL:ENSP00000419754 [DatabaseIdentifier:11573043] ENSEMBL:ENSP00000348512 [DatabaseIdentifier:11573041] ENSEMBL:ENSP00000353388 [DatabaseIdentifier:11573042] ENSEMBL:ENSP00000417510 [DatabaseIdentifier:11695743] ENSEMBL:ENST00000350612 [DatabaseIdentifier:11695741] ENSEMBL:ENST00000356185 [DatabaseIdentifier:11695742] ENSEMBL:ENST00000360252 [DatabaseIdentifier:11695740] ENSEMBL:ENST00000464744 [DatabaseIdentifier:11695739] ENSEMBL:ENST00000475892 [DatabaseIdentifier:11788974] GeneCards:SUPT20H [DatabaseIdentifier:11804602] GlyGen:Q8NEM7 [DatabaseIdentifier:11842000] HPA:ENSG00000102710-SUPT20H [DatabaseIdentifier:12126594] OpenTargets:ENSG00000102710 [DatabaseIdentifier:12141665] PDB:7KTR [DatabaseIdentifier:12141666] PDB:7KTS [DatabaseIdentifier:12141667] PDB:8H7G [DatabaseIdentifier:12267034] PRO:Q8NEM7 [DatabaseIdentifier:12286848] Pharos - Targets:Q8NEM7 [DatabaseIdentifier:12372965] RefSeq:NP_001265411.1 [DatabaseIdentifier:12372966] RefSeq:NP_001014308.2 [DatabaseIdentifier:12372963] RefSeq:XP_047286413.1 [DatabaseIdentifier:12372964] RefSeq:XP_054230667.1 [DatabaseIdentifier:12372959] RefSeq:NP_001265409.1 [DatabaseIdentifier:12372960] RefSeq:XP_047286405.1 [DatabaseIdentifier:12372961] RefSeq:NP_001265410.1 [DatabaseIdentifier:12372967] RefSeq:XP_054230676.1 [DatabaseIdentifier:12372962] RefSeq:NP_060039.1
databaseName	UniProt
dbId	229040
description	recommendedName: Transcription factor SPT20 homolog alternativeName: p38-interacting protein shortName: p38IP
displayName	UniProt:Q8NEM7 SUPT20H
geneName	SUPT20H C13orf19 FAM48A FP757
identifier	Q8NEM7
isSequenceChanged	false
keyword	3D-structure Alternative splicing Autophagy Developmental protein Gastrulation Nucleus Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SUPT20H
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3662286] SUPT20H [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000102710] ENSEMBL:ENSG00000102710 SUPT20H [ReferenceDNASequence:12739315] UCSC:Q8NEM7 SUPT20H [ReferenceDNASequence:11339587] BioGPS Gene:55578 SUPT20H [ReferenceDNASequence:11399779] COSMIC - genes:SUPT20H SUPT20H [ReferenceDNASequence:11415475] CTD Gene:55578 SUPT20H [ReferenceDNASequence:11436812] dbSNP Gene:55578 SUPT20H [ReferenceDNASequence:11820626] HGNC:20596 SUPT20H [ReferenceDNASequence:11880436] KEGG:hsa:55578 SUPT20H [ReferenceDNASequence:11969376] Monarch:55578 SUPT20H [ReferenceDNASequence:12053469] NCBI Gene:55578 SUPT20H [ReferenceDNASequence:12111573] OMIM:613417 SUPT20H
referenceTranscript	[ReferenceRNASequence:12554743] RefSeq:NM_001278481.2 SUPT20H [ReferenceRNASequence:12554736] RefSeq:NM_001278482.2 SUPT20H [ReferenceRNASequence:12554740] RefSeq:XM_054374701.1 SUPT20H [ReferenceRNASequence:12554741] RefSeq:XM_047430457.1 SUPT20H [ReferenceRNASequence:12554738] RefSeq:NM_001014286.3 SUPT20H [ReferenceRNASequence:12554737] RefSeq:XM_054374692.1 SUPT20H [ReferenceRNASequence:12554744] RefSeq:XM_047430449.1 SUPT20H [ReferenceRNASequence:12554739] RefSeq:NM_017569.4 SUPT20H [ReferenceRNASequence:12554742] RefSeq:NM_001278480.2 SUPT20H
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SP20H_HUMAN E7ER46 Q71RF3 Q9Y6A6
sequenceLength	779
species	[Species:48887] Homo sapiens
stId	uniprot:Q8NEM7
url	http://purl.uniprot.org/uniprot/Q8NEM7

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3662286] SUPT20H [nucleoplasm]
(interactor)	[UndirectedInteraction:11154539] UniProt:Q9Y4A5 <-> UniProt:Q8NEM7 (IntAct) [UndirectedInteraction:11219133] UniProt:P52294 <-> UniProt:Q8NEM7 (IntAct) [UndirectedInteraction:11265329] UniProt:Q96ES7 <-> UniProt:Q8NEM7 (IntAct) [UndirectedInteraction:11265737] UniProt:Q16539 <-> UniProt:Q8NEM7 (IntAct)

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