UniProt:Q8N6F1 CLDN19

chain
  • chain:1-224
checksum 60E1A21902415219
comment
  • FUNCTION Forms paracellular channels: coassembles with CLDN16 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (By similarity) (PubMed:17033971, PubMed:25555744). Forms paracellular barriers on its own. In the peripheral nervous system, represents a major constituent of the tight junctions in Schwann cells and contributes to electrical sealing. During retinal neurogenesis, may regulate the barrier properties of tight junctions in retinal pigment epithelium, required for proper retinal tissue differentiation and vision (By similarity) (PubMed:17033971, PubMed:30937396).CATALYTIC ACTIVITY Mg(2+)(in) = Mg(2+)(out)CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Rb(+)(in) = Rb(+)(out)CATALYTIC ACTIVITY Cs(+)(in) = Cs(+)(out)CATALYTIC ACTIVITY Li(+)(in) = Li(+)(out)SUBUNIT Can form homo- and heteropolymeric tight junction strands. Interacts with other claudins including CLDN3, CLDN10, CLDN16 and CLDN18 with highest affinity for CLDN16 (PubMed:18188451, PubMed:19706394, PubMed:28028216, PubMed:36008380). Interacts (via PDZ-binding motif TRV) with TJP1 (via PDZ domain) (By similarity).INTERACTION Cotrafficks with CLDN16 from ER to tight junctions. Colocalizes with CLDN16 and CLDN3 in cell-cell contact areas of the TAL spatially separated from CLDN10b paracellular channels.ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the claudin family.
crossReference
databaseName UniProt
dbId 52266
description
  • recommendedName: fullName evidence="15"Claudin-19
displayName UniProt:Q8N6F1 CLDN19
geneName
  • CLDN19
identifier Q8N6F1
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell junction
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Magnesium
  • Membrane
  • Primary hypomagnesemia
  • Proteomics identification
  • Reference proteome
  • Sensory transduction
  • Tight junction
  • Transmembrane
  • Transmembrane helix
  • Vision
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CLDN19
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CLD19_HUMAN
  • B7Z5I2
  • F5H5P9
  • Q5QT57
  • Q8N8X0
sequenceLength 224
species [Species:48887] Homo sapiens
stId uniprot:Q8N6F1
url http://purl.uniprot.org/uniprot/Q8N6F1
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