UniProt:Q8N661 TMEM86B

chain
  • chain:1-226
checksum BD5344268F221275
comment
  • FUNCTION Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen.CATALYTIC ACTIVITY a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholineCATALYTIC ACTIVITY a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamineACTIVITY REGULATION Competitively inhibited by lysophosphatidic acid.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and lysoplasmenyl-choline as substrates, respectively.SUBUNIT Homodimer.INTERACTION Belongs to the TMEM86 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 251818
description
  • recommendedName: Lysoplasmalogenase TMEM86B ecNumber evidence="4"3.3.2.2 alternativeName: Transmembrane protein 86B
displayName UniProt:Q8N661 TMEM86B
geneName
  • TMEM86B
identifier Q8N661
isSequenceChanged false
keyword
  • Cytoplasm
  • Endoplasmic reticulum
  • Hydrolase
  • Lipid metabolism
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • TMEM86B
otherIdentifier
  • 11754415_a_at
  • 16875677
  • 229736_PM_at
  • 229736_at
  • 255043
  • 3871243
  • 3871244
  • 3871245
  • 3871246
  • 3871247
  • 3871248
  • 3871249
  • 3871250
  • 3871251
  • 3871252
  • 3871253
  • 3871254
  • 3871255
  • 76852_at
  • 8039409
  • A_24_P121956
  • GE495160
  • GO:0005515
  • GO:0005737
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0016020
  • GO:0016787
  • GO:0016803
  • GO:0016853
  • GO:0036151
  • GO:0042802
  • GO:0046485
  • GO:0047408
  • GO:0047826
  • HMNXSV003036862
  • Hs.135215.0.A1_3p_at
  • ILMN_2049417
  • PH_hs_0008163
  • TC19001863.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TM86B_HUMAN
sequenceLength 226
species [Species:48887] Homo sapiens
stId uniprot:Q8N661
url http://purl.uniprot.org/uniprot/Q8N661

Referrals

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