UniProt:Q8N3T1 GALNT15

chain
  • chain:1-639
checksum F5DCA523AF4965DA
comment
  • FUNCTION Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.CATALYTIC ACTIVITY L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)COFACTOR Protein modification; protein glycosylation.INTERACTION Widely expressed. Highly expressed in small intestine, placenta, spleen, cerebral cortex and ovary. Expressed at intermediate level in uterus, mammary gland, stomach, cerebellum and whole brain. Weakly expressed in fetal brain, bone marrow, thyroid gland, thymus, heart, skeletal muscle, lung, liver, colon, pancreas, kidney and testis. Not expressed in leukocyte. Expressed in both normal and osteoarthritic cartilage. Expressed at low level in chondrocytes in all zones of both normal and osteoarthritic cartilage.DOMAIN There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.DOMAIN The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.SIMILARITY Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.CAUTION Was originally termed Galnt15/pp-GaNTase 15.SEQUENCE CAUTION Polypeptide N-acetylgalactosaminyltransferase-like protein 2
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 148257
description
  • recommendedName: Polypeptide N-acetylgalactosaminyltransferase 15 ecNumber evidence="6"2.4.1.41 alternativeName: Polypeptide GalNAc transferase-like protein 2 shortName: GalNAc-T-like protein 2 shortName: pp-GaNTase-like protein 2 alternativeName: Polypeptide N-acetylgalactosaminyltransferase-like protein 2 alternativeName: Protein-UDP acetylgalactosaminyltransferase-like protein 2 alternativeName: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2
displayName UniProt:Q8N3T1 GALNT15
geneName
  • GALNT15
  • GALNTL2
  • UNQ770/PRO1564
identifier Q8N3T1
isSequenceChanged false
keyword
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Lectin
  • Manganese
  • Membrane
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • GALNT15
otherIdentifier
  • 117248
  • 11726078_a_at
  • 11726079_x_at
  • 11726080_a_at
  • 11758950_at
  • 16938133
  • 228501_PM_at
  • 228501_at
  • 236361_PM_at
  • 236361_at
  • 239461_PM_at
  • 239461_at
  • 2612569
  • 2612570
  • 2612571
  • 2612572
  • 2612576
  • 2612578
  • 2612579
  • 2612581
  • 2612582
  • 2612583
  • 2612585
  • 2612586
  • 2612588
  • 2612590
  • 2612591
  • 2612592
  • 2612593
  • 2612594
  • 2612595
  • 2612596
  • 2612597
  • 2612598
  • 2612599
  • 2612600
  • 2612601
  • 2612602
  • 2612603
  • 2612604
  • 53672_at
  • 70649_at
  • 75045_at
  • 75451_s_at
  • 8078155
  • 87006_at
  • 88033_at
  • A_14_P112587
  • A_23_P212119
  • GE736463
  • GO:0000139
  • GO:0003824
  • GO:0004653
  • GO:0005515
  • GO:0005794
  • GO:0006486
  • GO:0006493
  • GO:0016020
  • GO:0016266
  • GO:0016740
  • GO:0016757
  • GO:0030133
  • GO:0030246
  • GO:0031410
  • GO:0046872
  • GO:0140096
  • HMNXSV003038495
  • HMNXSV003048786
  • Hs.135130.0.A1_3p_at
  • Hs.238532.0.A1_3p_at
  • Hs.63163.0.A1_3p_at
  • ILMN_1813104
  • PH_hs_0024865
  • TC03000101.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GLT15_HUMAN
  • A6NMN1
  • B2R638
  • F1LIP6
  • Q86T60
  • Q96C46
  • Q96DJ5
sequenceLength 639
species [Species:48887] Homo sapiens
stId uniprot:Q8N3T1
url http://purl.uniprot.org/uniprot/Q8N3T1
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