Reactome | UniProt:Q8N1F7 NUP93

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UniProt:Q8N1F7 NUP93 Show undefined attributes

chain	chain:1-819
checksum	7A611FABE964FE98
comment	FUNCTION Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).SUBUNIT Part of the nuclear pore complex (NPC) (PubMed:15229283, PubMed:15703211, PubMed:9348540). Component of the p62 complex, a complex composed of NUP62 and NUP54 (PubMed:9348540). Forms a complex with NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is direct (PubMed:15703211). Does not interact with TPR (PubMed:12802065, PubMed:15229283). Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (PubMed:26878725).SUBUNIT (Microbial infection) Interacts with SARS-CoV translation inhibitor nsp1; this interaction may disrupt nuclear pore function.INTERACTION Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the nucleoporin interacting component (NIC) family.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:11501143] ENSEMBL:ENSG00000102900 [DatabaseIdentifier:11611571] ENSEMBL:ENSP00000440235 [DatabaseIdentifier:11611572] ENSEMBL:ENSP00000458039 [DatabaseIdentifier:11611570] ENSEMBL:ENSP00000310668 [DatabaseIdentifier:11734271] ENSEMBL:ENST00000542526 [DatabaseIdentifier:11734270] ENSEMBL:ENST00000564887 [DatabaseIdentifier:11734269] ENSEMBL:ENST00000308159 [DatabaseIdentifier:11793677] GeneCards:NUP93 [DatabaseIdentifier:11809642] GlyGen:Q8N1F7 [DatabaseIdentifier:11846666] HPA:ENSG00000102900-NUP93 [DatabaseIdentifier:12131326] OpenTargets:ENSG00000102900 [DatabaseIdentifier:12135728] Orphanet:NUP93 [DatabaseIdentifier:12219074] PDB:7MW0 [DatabaseIdentifier:12160445] PDB:5IJO [DatabaseIdentifier:12188507] PDB:7MW1 [DatabaseIdentifier:12140500] PDB:7R5J [DatabaseIdentifier:12140501] PDB:7R5K [DatabaseIdentifier:12160446] PDB:5IJN [DatabaseIdentifier:12160447] PDB:7PER [DatabaseIdentifier:12253554] PRO:Q8N1F7 [DatabaseIdentifier:12291518] Pharos - Targets:Q8N1F7 [DatabaseIdentifier:12430801] RefSeq:NP_001229724.1 [DatabaseIdentifier:12430802] RefSeq:XP_005256320.1 [DatabaseIdentifier:12430804] RefSeq:XP_054170460.1 [DatabaseIdentifier:12430805] RefSeq:NP_001229725.1 [DatabaseIdentifier:12430803] RefSeq:NP_055484.3
databaseName	UniProt
dbId	151387
description	recommendedName: Nuclear pore complex protein Nup93 alternativeName: 93 kDa nucleoporin alternativeName: Nucleoporin Nup93
displayName	UniProt:Q8N1F7 NUP93
geneName	NUP93 KIAA0095
identifier	Q8N1F7
isSequenceChanged	false
keyword	3D-structure Alternative splicing Disease variant Membrane mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transport
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NUP93
otherIdentifier	11754814_a_at 16819269 202188_PM_at 202188_at 241758_PM_at 241758_at 3662269 3662273 3662274 3662275 3662277 3662280 3662281 3662282 3662289 3662290 3662291 3662292 3662293 3662294 3662295 3662296 3662299 3662300 3662301 3662302 3662303 3662304 3662305 3662306 3662307 3662308 3662309 3662310 3662311 3662312 3662313 3662314 3662315 3662316 3662317 3662320 3662324 3662325 3662326 3662327 3662328 3662330 3662332 3662334 40271_at 58171_r_at 7995843 83430_at 9688 A_14_P133975 A_23_P89056 A_32_P163908 A_32_P174223 D42085_at GE57209 GE681763 GE716009 GO:0005515 GO:0005634 GO:0005635 GO:0005643 GO:0005813 GO:0005815 GO:0005829 GO:0006606 GO:0006886 GO:0006913 GO:0006998 GO:0015031 GO:0016020 GO:0016973 GO:0017056 GO:0031965 GO:0034399 GO:0051028 GO:0051292 GO:0060391 GO:0061024 GO:0065003 HMNXSV003039722 Hs.177230.0.A1_3p_at ILMN_2196569 PH_hs_0023563 TC16000477.hg g7661901_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-157749] NUP93 [nuclear envelope] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9634167] NUP93 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000102900] ENSEMBL:ENSG00000102900 NUP93 [ReferenceDNASequence:12703349] UCSC:Q8N1F7 NUP93 [ReferenceDNASequence:11366465] BioGPS Gene:9688 NUP93 [ReferenceDNASequence:11394696] COSMIC - genes:NUP93 NUP93 [ReferenceDNASequence:11422223] CTD Gene:9688 NUP93 [ReferenceDNASequence:11430796] dbSNP Gene:9688 NUP93 [ReferenceDNASequence:11825370] HGNC:28958 NUP93 [ReferenceDNASequence:11904884] KEGG:hsa:9688 NUP93 [ReferenceDNASequence:11996254] Monarch:9688 NUP93 [ReferenceDNASequence:12080347] NCBI Gene:9688 NUP93 [ReferenceDNASequence:12115792] OMIM:614351 NUP93
referenceTranscript	[ReferenceRNASequence:12612317] RefSeq:XM_005256263.4 NUP93 [ReferenceRNASequence:12612315] RefSeq:NM_001242796.2 NUP93 [ReferenceRNASequence:12612318] RefSeq:XM_054314485.1 NUP93 [ReferenceRNASequence:12612316] RefSeq:NM_001242795.2 NUP93 [ReferenceRNASequence:12612319] RefSeq:NM_014669.4 NUP93
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NUP93_HUMAN B3KPQ8 Q14705
sequenceLength	819
species	[Species:48887] Homo sapiens
stId	uniprot:Q8N1F7
url	http://purl.uniprot.org/uniprot/Q8N1F7

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