UniProt:Q8IYI6 EXOC8

chain
  • chain:1-725
checksum F4E5E344EF24FDCA
comment
  • FUNCTION Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.SUBUNIT The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts (via PH domain) with GTP-bound RALA and RALB (PubMed:14525976, PubMed:18756269). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).INTERACTION Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Localizes at the leading edge of migrating cells (By similarity).DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the EXO84 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228619
description
  • recommendedName: Exocyst complex component 8 alternativeName: Exocyst complex 84 kDa subunit
displayName UniProt:Q8IYI6 EXOC8
geneName
  • EXOC8
identifier Q8IYI6
isSequenceChanged false
keyword
  • Cell projection
  • Cytoplasm
  • Disease variant
  • Epilepsy
  • Exocytosis
  • Phosphoprotein
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • EXOC8
otherIdentifier
  • 11728131_at
  • 11728132_s_at
  • 149371
  • 16700485
  • 227577_PM_at
  • 227577_at
  • 244502_PM_at
  • 244502_at
  • 2460524
  • 2460525
  • 2460526
  • 2460527
  • 2460528
  • 2460529
  • 2460530
  • 2460531
  • 2460532
  • 2460533
  • 2460534
  • 2460535
  • 2460537
  • 61351_at
  • 7925043
  • 82133_at
  • A_23_P430161
  • A_32_P233314
  • A_33_P3397051
  • GE506801
  • GO:0000145
  • GO:0000281
  • GO:0000910
  • GO:0005515
  • GO:0005737
  • GO:0005768
  • GO:0005770
  • GO:0005829
  • GO:0005886
  • GO:0006887
  • GO:0006893
  • GO:0006904
  • GO:0007032
  • GO:0008104
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016241
  • GO:0022617
  • GO:0030198
  • GO:0030426
  • GO:0031267
  • GO:0035091
  • GO:0042995
  • GO:0048471
  • GO:0061024
  • GO:0071944
  • GO:0090148
  • GO:0090522
  • HMNXSV003009959
  • Hs.120828.0.S1_3p_at
  • Hs.163222.0.A1_3p_at
  • ILMN_2083818
  • PH_hs_0017264
  • TC01003967.hg
  • TC01006191.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EXOC8_HUMAN
  • B3KU33
  • Q5TE82
sequenceLength 725
species [Species:48887] Homo sapiens
stId uniprot:Q8IYI6
url http://purl.uniprot.org/uniprot/Q8IYI6

Referrals

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