UniProt:Q8IXI1 RHOT2

chain
  • chain:1-618
checksum C72ECBCA33D04B6B
comment
  • FUNCTION Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)CATALYTIC ACTIVITY UTP + H2O = UDP + phosphate + H(+)SUBUNIT Homodimer (PubMed:27605430). Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with ARMCX3 (By similarity). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (PubMed:24995978).INTERACTION Colocalizes with MGARP and RHOT2 at the mitochondria.ALTERNATIVE PRODUCTS Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.DOMAIN The Miro 2 domain is necessary for efficient ubiquitination by PRKN.PTM Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.SIMILARITY Belongs to the mitochondrial Rho GTPase family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 410886
description
  • recommendedName: Mitochondrial Rho GTPase 2 shortName: MIRO-2 shortName: hMiro-2 ecNumber evidence="1"3.6.5.- alternativeName: Ras homolog gene family member T2
displayName UniProt:Q8IXI1 RHOT2
geneName
  • RHOT2
  • ARHT2
  • C16orf39
identifier Q8IXI1
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • GTP-binding
  • Hydrolase
  • Isopeptide bond
  • Magnesium
  • Membrane
  • Metal-binding
  • Mitochondrion
  • Mitochondrion outer membrane
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transmembrane
  • Transmembrane helix
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RHOT2
otherIdentifier
  • 11737635_a_at
  • 11744386_a_at
  • 16814455
  • 221789_3p_x_at
  • 221789_PM_x_at
  • 221789_x_at
  • 222131_3p_x_at
  • 222131_PM_x_at
  • 222131_x_at
  • 3643228
  • 3643230
  • 3643231
  • 3643232
  • 3643233
  • 3643234
  • 3643235
  • 3643236
  • 3643237
  • 3643238
  • 3643239
  • 3643240
  • 3643241
  • 3643242
  • 3643243
  • 3643244
  • 3643245
  • 3643246
  • 3643247
  • 3643248
  • 3643249
  • 3643250
  • 3643251
  • 3643252
  • 3643253
  • 3643254
  • 3643255
  • 3643256
  • 3643257
  • 3643258
  • 3643259
  • 3643260
  • 3643261
  • 3643262
  • 3643263
  • 3643264
  • 3643265
  • 3643266
  • 3643267
  • 3643268
  • 3643269
  • 3643270
  • 3643271
  • 4890925_3p_x_at
  • 65770_PM_at
  • 65770_at
  • 7991989
  • 89941
  • A_14_P120738
  • A_23_P15067
  • A_33_P3393350
  • GE57005
  • GE63276
  • GO:0000166
  • GO:0000287
  • GO:0003924
  • GO:0005509
  • GO:0005515
  • GO:0005525
  • GO:0005739
  • GO:0005741
  • GO:0007005
  • GO:0007018
  • GO:0007264
  • GO:0016020
  • GO:0016787
  • GO:0016887
  • GO:0019003
  • GO:0019725
  • GO:0046872
  • GO:0047497
  • GO:0097345
  • HMNXSV003031803
  • Hs.21497.0.S1_3p_s_at
  • Hs.21497.1.S1_3p_s_at
  • Hs.21497.1.S1_3p_x_at
  • ILMN_1669310
  • PH_hs_0025948
  • TC16000024.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MIRO2_HUMAN
  • A2IDC2
  • Q8NF53
  • Q96C13
  • Q96S17
  • Q9BT60
  • Q9H7M8
sequenceLength 618
species [Species:48887] Homo sapiens
stId uniprot:Q8IXI1
url http://purl.uniprot.org/uniprot/Q8IXI1
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