UniProt:Q8IX12 CCAR1

chain
  • chain:1-1150
checksum 30618DCC8097F552
comment
  • FUNCTION Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).SUBUNIT Directly interacts with ESR1, NR3C1 and p53/TP53 (By similarity). Interacts (via N-terminus) with CALCOCO1. Interacts with MED1 (By similarity). Interacts with GATA1. Interacts with AR and GATA2.INTERACTION Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 221944
description
  • recommendedName: Cell division cycle and apoptosis regulator protein 1 alternativeName: Cell cycle and apoptosis regulatory protein 1 shortName: CARP-1 alternativeName: Death inducer with SAP domain
displayName UniProt:Q8IX12 CCAR1
geneName
  • CCAR1
  • CARP1
  • DIS
identifier Q8IX12
isSequenceChanged false
keyword
  • Activator
  • Alternative splicing
  • Apoptosis
  • Cell cycle
  • Coiled coil
  • Cytoplasm
  • Isopeptide bond
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CCAR1
otherIdentifier
  • 11742972_x_at
  • 11756283_s_at
  • 16705399
  • 17118760
  • 224736_PM_at
  • 224736_at
  • 224737_PM_x_at
  • 224737_x_at
  • 3249814
  • 3249815
  • 3249816
  • 3249817
  • 3249818
  • 3249821
  • 3249822
  • 3249823
  • 3249824
  • 3249825
  • 3249826
  • 3249827
  • 3249828
  • 3249829
  • 3249830
  • 3249831
  • 3249832
  • 3249834
  • 3249836
  • 3249838
  • 3249839
  • 3249842
  • 3249843
  • 3249844
  • 3249845
  • 3249846
  • 3249848
  • 3249849
  • 3249850
  • 3249852
  • 3249853
  • 3249854
  • 3249858
  • 3249861
  • 3249862
  • 3249863
  • 3249864
  • 3249865
  • 3249866
  • 3249867
  • 3249868
  • 3249869
  • 3249870
  • 3249871
  • 3249872
  • 3249873
  • 3249874
  • 3543778
  • 47320_at
  • 55749
  • 57876_at
  • 57878_g_at
  • 65214_at
  • 73758_at
  • 7927889
  • 84902_r_at
  • A_14_P109779
  • A_14_P139183
  • A_21_P0000392
  • A_23_P115842
  • GE87165
  • GO:0000978
  • GO:0003713
  • GO:0003714
  • GO:0003723
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005641
  • GO:0005654
  • GO:0005737
  • GO:0006355
  • GO:0006511
  • GO:0006915
  • GO:0008284
  • GO:0016567
  • GO:0016740
  • GO:0030335
  • GO:0043065
  • GO:0045892
  • GO:0045893
  • GO:0048471
  • GO:0061630
  • GO:0140096
  • HMNXSV003002465
  • HMNXSV003057955
  • Hs.183779.0.A1_3p_at
  • Hs.183779.0.A2_3p_at
  • ILMN_1679127
  • PH_hs_0025981
  • PH_hs_0039088
  • RNA33769|snoRNA_scaRNA_365_67
  • TC10000408.hg
  • p33902
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CCAR1_HUMAN
  • A0JLT7
  • A1L4P7
  • A8K9D4
  • B4DNP8
  • B4DRK8
  • Q32NE3
  • Q5EBM3
  • Q5VUP6
  • Q6PIZ0
  • Q6X935
  • Q9H8N4
  • Q9NVA7
  • Q9NVQ0
  • Q9NWM6
sequenceLength 1150
species [Species:48887] Homo sapiens
stId uniprot:Q8IX12
url http://purl.uniprot.org/uniprot/Q8IX12
Cite Us!