FUNCTION Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.SUBUNIT Homodimer and homooligomer. Interacts with microtubules. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.INTERACTION Ubiquitous.DOMAIN The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro.DOMAIN The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the translokin family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Extended N-terminus.
recommendedName: Centrosomal protein of 57 kDa shortName: Cep57 alternativeName: FGF2-interacting protein alternativeName: Testis-specific protein 57 alternativeName: Translokin
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