Reactome | UniProt:Q86WI3 NLRC5

Schema > ReferenceGeneProduct > Entries

UniProt:Q86WI3 NLRC5 Show undefined attributes

chain	chain:1-1866
checksum	4E3BDED8E1624967
comment	FUNCTION Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.SUBUNIT Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with RIGI and IFIH1; blocks the interaction of MAVS to RIGI.SUBCELLULAR LOCATION Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.INDUCTION By IFNG/IFN-gamma.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the NLRP family.CAUTION Supposed to contain a CARD domain at the N-terminus (PubMed:20434986). However, this domain is not detected by Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12398641] RefSeq:NP_001371879.1 [DatabaseIdentifier:12398642] RefSeq:NP_001371900.1 [DatabaseIdentifier:12398643] RefSeq:NP_115582.4 [DatabaseIdentifier:12398644] RefSeq:NP_001317481.1 [DatabaseIdentifier:12398645] RefSeq:NP_001371880.1 [DatabaseIdentifier:12280592] Pharos - Targets:Q86WI3 [DatabaseIdentifier:12237577] PRO:Q86WI3 [DatabaseIdentifier:12120256] OpenTargets:ENSG00000140853 [DatabaseIdentifier:11835793] HPA:ENSG00000140853-NLRC5 [DatabaseIdentifier:11798334] GlyGen:Q86WI3 [DatabaseIdentifier:11782678] GeneCards:NLRC5 [DatabaseIdentifier:11779745] Guide to Pharmacology - Targets:1765 [DatabaseIdentifier:11712288] ENSEMBL:ENST00000688547 [DatabaseIdentifier:11712290] ENSEMBL:ENST00000539144 [DatabaseIdentifier:11712287] ENSEMBL:ENST00000262510 [DatabaseIdentifier:11712289] ENSEMBL:ENST00000539881 [DatabaseIdentifier:11589590] ENSEMBL:ENSP00000262510 [DatabaseIdentifier:11589589] ENSEMBL:ENSP00000441679 [DatabaseIdentifier:11589591] ENSEMBL:ENSP00000509992 [DatabaseIdentifier:11589588] ENSEMBL:ENSP00000441727 [DatabaseIdentifier:11485951] ENSEMBL:ENSG00000140853
databaseName	UniProt
dbId	239736
description	recommendedName: Protein NLRC5 alternativeName: Caterpiller protein 16.1 shortName: CLR16.1 alternativeName: Nucleotide-binding oligomerization domain protein 27 alternativeName: Nucleotide-binding oligomerization domain protein 4
displayName	UniProt:Q86WI3 NLRC5
geneName	NLRC5 NOD27 NOD4
identifier	Q86WI3
isSequenceChanged	false
keyword	Alternative splicing ATP-binding Cytoplasm Immunity Innate immunity Leucine-rich repeat Nucleotide-binding Proteomics identification Reference proteome Repeat
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NLRC5
otherIdentifier	11729523_a_at 11755758_s_at 16819355 226474_PM_at 226474_at 3662445 3662446 3662447 3662448 3662451 3662453 3662454 3662457 3662458 3662459 3662460 3662461 3662462 3662463 3662464 3662465 3662466 3662467 3662468 3662469 3662470 3662471 3662472 3662474 3662476 3662477 3662479 3662480 3662481 3662482 3662483 3662484 3662486 3662488 3662489 3662490 3662491 3662492 3662493 3662494 3662495 3662496 3662497 3662498 3662499 3662500 3662501 3662502 3662503 3662504 3662505 3662506 3662508 3662509 3662510 3662511 3662512 3662513 3662514 3662515 3662516 3662517 3662518 3662520 3662521 3662522 3662523 3662524 3662525 3662526 3662527 3662528 3662529 3662530 3662531 3662532 3662533 3662534 3662535 3662536 3662537 3662538 3662539 3662540 3662541 3662543 48099_at 66966_at 69683_at 7995926 84166 A_32_P416583 GE83335 GO:0000166 GO:0000978 GO:0002376 GO:0005096 GO:0005515 GO:0005524 GO:0005634 GO:0005737 GO:0005813 GO:0005815 GO:0005829 GO:0005856 GO:0006355 GO:0009617 GO:0032088 GO:0043549 GO:0045087 GO:0045345 GO:0045944 GO:0051607 GO:0060335 GO:0060339 GO:0060340 GO:0098542 GO:0098772 HMNXSV003019860 HMNXSV003044372 HMNXSV003050308 Hs.10888.0.S1_3p_at ILMN_1716704 PH_hs_0024279 TC16000482.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9750938] K63polyUb-NLRC5 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-937324] NLRC5 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12745526] UCSC:Q86WI3 NLRC5 [ReferenceDNASequence:12106081] OMIM:613537 NLRC5 [ReferenceDNASequence:12065137] NCBI Gene:84166 NLRC5 [ReferenceDNASequence:11981044] Monarch:84166 NLRC5 [ReferenceDNASequence:11891030] KEGG:hsa:84166 NLRC5 [ReferenceDNASequence:11814286] HGNC:29933 NLRC5 [ReferenceDNASequence:11437911] dbSNP Gene:84166 NLRC5 [ReferenceDNASequence:11406123] CTD Gene:84166 NLRC5 [ReferenceDNASequence:11400709] COSMIC - genes:NLRC5 NLRC5 [ReferenceDNASequence:11351255] BioGPS Gene:84166 NLRC5 [ReferenceDNASequence:ensembl:ENSG00000140853] ENSEMBL:ENSG00000140853 NLRC5
referenceTranscript	[ReferenceRNASequence:12580350] RefSeq:NM_001384971.1 NLRC5 [ReferenceRNASequence:12580349] RefSeq:NM_001384950.1 NLRC5 [ReferenceRNASequence:12580351] RefSeq:NM_001384951.1 NLRC5 [ReferenceRNASequence:12580353] RefSeq:NM_001330552.2 NLRC5 [ReferenceRNASequence:12580352] RefSeq:NM_032206.4 NLRC5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NLRC5_HUMAN B5MEF1 C9JMD8 Q6P4A6 Q86VM7 Q8NF42 Q8TEE2 Q8TEJ1 Q969L7
sequenceLength	1866
species	[Species:48887] Homo sapiens
stId	uniprot:Q86WI3
url	http://purl.uniprot.org/uniprot/Q86WI3

Referrals

(interactor)	[UndirectedInteraction:11171853] UniProt:Q86WI3 <-> UniProt:O15111 (IntAct) [UndirectedInteraction:11171851] UniProt:Q86WI3 <-> UniProt:O14920 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9750938] K63polyUb-NLRC5 [cytosol] [EntityWithAccessionedSequence:R-HSA-937324] NLRC5 [cytosol]
(referenceSequence)	[GroupModifiedResidue:9750945] ubiquitinylated lysine (K63polyUb [cytosol]) at 1178