Reactome | UniProt:Q86VP6 CAND1

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UniProt:Q86VP6 CAND1 Show undefined attributes

chain	initiator methionine:1 chain:2-1230
checksum	FE344558F72D79D8
comment	FUNCTION Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.SUBUNIT Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with ERCC6 (PubMed:26030138). Interacts with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions are bridged by cullins and strongly inhibits the neddylation of cullins (PubMed:24192928, PubMed:25349211, PubMed:26906416).INTERACTION Predominantly cytoplasmic.ALTERNATIVE PRODUCTS Repressed by miR-148a.MISCELLANEOUS A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate' deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757).SIMILARITY Belongs to the CAND family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12143980] PDB:8OR3 [DatabaseIdentifier:12400104] RefSeq:NP_060918.2 [DatabaseIdentifier:12281072] Pharos - Targets:Q86VP6 [DatabaseIdentifier:12238379] PRO:Q86VP6 [DatabaseIdentifier:12143973] PDB:8CDJ [DatabaseIdentifier:12143968] PDB:7Z8T [DatabaseIdentifier:12143966] PDB:1U6G [DatabaseIdentifier:11486480] ENSEMBL:ENSG00000111530 [DatabaseIdentifier:11590562] ENSEMBL:ENSP00000442318 [DatabaseIdentifier:11713261] ENSEMBL:ENST00000545606 [DatabaseIdentifier:11783158] GeneCards:CAND1 [DatabaseIdentifier:11798768] GlyGen:Q86VP6 [DatabaseIdentifier:11836265] HPA:ENSG00000111530-CAND1 [DatabaseIdentifier:12120738] OpenTargets:ENSG00000111530 [DatabaseIdentifier:12143981] PDB:8OR4 [DatabaseIdentifier:12143986] PDB:8OR2 [DatabaseIdentifier:12143971] PDB:8CDK [DatabaseIdentifier:12143987] PDB:8OR0 [DatabaseIdentifier:12143965] PDB:7ZBZ [DatabaseIdentifier:12143967] PDB:7ZBW [DatabaseIdentifier:12143970] PDB:7Z8R [DatabaseIdentifier:12144150] PDB:4A0C [DatabaseIdentifier:12143992] PDB:7Z8V [DatabaseIdentifier:12143922] PDB:8H3Q
databaseName	UniProt
dbId	221237
description	recommendedName: Cullin-associated NEDD8-dissociated protein 1 alternativeName: Cullin-associated and neddylation-dissociated protein 1 alternativeName: TBP-interacting protein of 120 kDa A shortName: TBP-interacting protein 120A alternativeName: p120 CAND1
displayName	UniProt:Q86VP6 CAND1
geneName	CAND1 KIAA0829 TIP120 TIP120A
identifier	Q86VP6
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation pathway
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	CAND1
otherIdentifier	11719937_a_at 11719938_s_at 11719939_a_at 1556318_3p_s_at 1556318_PM_s_at 1556318_s_at 16753712 207483_PM_s_at 207483_s_at 208838_PM_at 208838_at 208839_PM_s_at 208839_s_at 235224_PM_s_at 235224_s_at 239771_PM_at 239771_at 243910_PM_x_at 243910_x_at 32196_at 3420716 3420717 3420718 3420719 3420720 3420721 3420722 3420724 3420727 3420728 3420729 3420734 3420735 3420736 3420737 3420738 3420739 3420740 3420741 3420742 3420744 3420745 3420746 3420747 3420750 3420753 3420754 3420755 3420756 3420757 3420758 3420759 3420760 3420761 3420762 3420764 3420766 3420768 3420770 3420772 3420774 50546_at 55832 59523_at 68781_at 7956910 86969_at 88937_at A_14_P131977 A_14_P135815 A_23_P25137 A_23_P25141 A_24_P47681 A_32_P150418 A_32_P232237 GE62226 GE82377 GE893252 GO:0000151 GO:0005515 GO:0005576 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005829 GO:0006355 GO:0010265 GO:0016020 GO:0016567 GO:0017025 GO:0030154 GO:0031461 GO:0034774 GO:0043086 GO:0045893 GO:0045899 GO:0065003 GO:0070062 GO:1904813 HMNXSV003013627 HMNXSV003015307 Hs.128521.0.S1_3p_at Hs.200073.0.A1_3p_s_at Hs.209521.0.A1_3p_at Hs2.397035.1.A1_3p_at Hs2.397035.1.A1_3p_s_at ILMN_1744647 PH_hs_0026787 TC12000595.hg TC12002426.hg g12053130_3p_a_at g8924259_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5691146] CAND1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801399] CAND1 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806498] CAND1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801390] CAND1 [secretory granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8955089] CAND1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000111530] ENSEMBL:ENSG00000111530 CAND1 [ReferenceDNASequence:12745780] UCSC:Q86VP6 CAND1 [ReferenceDNASequence:11351761] BioGPS Gene:55832 CAND1 [ReferenceDNASequence:11400798] COSMIC - genes:CAND1 CAND1 [ReferenceDNASequence:11406760] CTD Gene:55832 CAND1 [ReferenceDNASequence:11438023] dbSNP Gene:55832 CAND1 [ReferenceDNASequence:11814770] HGNC:30688 CAND1 [ReferenceDNASequence:11891506] KEGG:hsa:55832 CAND1 [ReferenceDNASequence:11981550] Monarch:55832 CAND1 [ReferenceDNASequence:12065643] NCBI Gene:55832 CAND1 [ReferenceDNASequence:12106515] OMIM:607727 CAND1
referenceTranscript	[ReferenceRNASequence:12581814] RefSeq:NM_018448.4 CAND1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CAND1_HUMAN B2RAU3 O94918 Q6PIY4 Q8NDJ4 Q96JZ9 Q96T19 Q9BTC4 Q9H0G2 Q9P0H7 Q9UF85
sequenceLength	1230
species	[Species:48887] Homo sapiens
stId	uniprot:Q86VP6
url	http://purl.uniprot.org/uniprot/Q86VP6

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