UniProt:Q86UT5 NHERF4

chain
  • chain:1-571
checksum B56CDC91348EE592
comment
  • FUNCTION Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).SUBUNIT Interacts with the C-terminal region of GUCY2C (PubMed:11950846). Interacts with the C-terminal region SLC9A3 and the interactions decrease in response to elevated calcium ion levels (PubMed:19088451). Interacts with the C-terminal region of SLC34A1 (By similarity). Interacts with USP2 isoform 4 (PubMed:26756164). Interacts (via the third PDZ domain) with SLC26A3 (via PDZ-binding motif); interaction leads to decreased expression of SLC26A3 on the cell membrane resulting in its reduced exchanger activity (PubMed:22627094).INTERACTION Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).ALTERNATIVE PRODUCTS Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.PTM Phosphorylation at Ser-395 negatively regulates its interaction with SLC26A3.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 242350
description
  • recommendedName: Na(+)/H(+) exchange regulatory cofactor NHE-RF4 shortName: NHERF-4 alternativeName: Intestinal and kidney-enriched PDZ protein alternativeName: Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 shortName: Na/Pi cotransporter C-terminal-associated protein 2 shortName: NaPi-Cap2 alternativeName: PDZ domain-containing protein 2 alternativeName: PDZ domain-containing protein 3 alternativeName: Sodium-hydrogen exchanger regulatory factor 4
displayName UniProt:Q86UT5 NHERF4
geneName
  • NHERF4
  • IKEPP
  • PDZD3
  • PDZK2
  • DLNB27
identifier Q86UT5
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cytoplasm
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • NHERF4
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NHRF4_HUMAN
  • Q8N6R4
  • Q8NAW7
  • Q8NEX7
  • Q9H5Z3
sequenceLength 571
species [Species:48887] Homo sapiens
stId uniprot:Q86UT5
url http://purl.uniprot.org/uniprot/Q86UT5
Cite Us!