UniProt:Q86US8 SMG6

chain
  • chain:1-1419
checksum 93FC7DDA68BD218C
comment
  • FUNCTION Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629).FUNCTION Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030).COFACTOR May form homooligomers (PubMed:20930030). Associated component of the telomerase holoenzyme complex (PubMed:19179534). Interacts with TERT, independently of the telomerase RNA (PubMed:12676087, PubMed:12699629). Interacts with SMG1, SMG5, SMG7, UPF1, UPF2, UPF3B and the PP2A catalytic subunits (PubMed:12554878, PubMed:19060897, PubMed:20930030). Also interacts with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A; required for the process of nonsense-mediated mRNA decay (PubMed:20930030). Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).INTERACTION Particularly enriched in the nucleolus.ALTERNATIVE PRODUCTS Ubiquitous.DOMAIN The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 147068
description
  • recommendedName: fullName evidence="18"Telomerase-binding protein EST1A ecNumber evidence="7"3.1.-.- alternativeName: fullName evidence="15"Ever shorter telomeres 1A shortName evidence="15"hEST1A alternativeName: fullName evidence="20"Nonsense mediated mRNA decay factor SMG6 alternativeName: fullName evidence="20"Smg-6 homolog alternativeName: fullName evidence="14"hSmg5/7a
displayName UniProt:Q86US8 SMG6
geneName
  • SMG6
  • C17orf31
  • EST1A
  • KIAA0732
identifier Q86US8
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Chromosome
  • Coiled coil
  • Cytoplasm
  • DNA-binding
  • Endonuclease
  • Hydrolase
  • Manganese
  • Metal-binding
  • Methylation
  • Nonsense-mediated mRNA decay
  • Nuclease
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Telomere
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • SMG6
otherIdentifier
  • 11720869_a_at
  • 11745314_a_at
  • 16839554
  • 214940_PM_s_at
  • 214940_s_at
  • 23293
  • 33798_at
  • 3740837
  • 3740839
  • 3740840
  • 3740841
  • 3740842
  • 3740843
  • 3740844
  • 3740849
  • 3740853
  • 3740854
  • 3740855
  • 3740861
  • 3740862
  • 3740863
  • 3740865
  • 3740866
  • 3740868
  • 3740869
  • 3740870
  • 3740873
  • 3740874
  • 3740875
  • 3740876
  • 3740877
  • 3740896
  • 3740897
  • 3740898
  • 3740899
  • 3740900
  • 3740901
  • 3740902
  • 3740906
  • 3740907
  • 3740919
  • 3740924
  • 3740925
  • 3740926
  • 3740927
  • 3740932
  • 3740936
  • 3740941
  • 3740942
  • 3740943
  • 3740944
  • 3740945
  • 3740946
  • 3740948
  • 3740949
  • 3740954
  • 3740955
  • 69338_at
  • 8011222
  • 83681_at
  • A_23_P100676
  • GE56630
  • GO:0000184
  • GO:0000781
  • GO:0003677
  • GO:0003723
  • GO:0003824
  • GO:0004518
  • GO:0004519
  • GO:0004521
  • GO:0005515
  • GO:0005634
  • GO:0005694
  • GO:0005697
  • GO:0005730
  • GO:0005737
  • GO:0005815
  • GO:0005829
  • GO:0005886
  • GO:0006406
  • GO:0006913
  • GO:0016787
  • GO:0032204
  • GO:0032210
  • GO:0035145
  • GO:0035303
  • GO:0036064
  • GO:0042162
  • GO:0043021
  • GO:0046872
  • GO:0070034
  • GO:0070182
  • GO:0140098
  • GO:1904354
  • HMNXSV003000426
  • HMNXSV003031015
  • Hs.20185.1.S1_3p_a_at
  • ILMN_1695280
  • PH_hs_0026197
  • TC17000988.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EST1A_HUMAN
  • B7Z874
  • O94837
  • Q86VH6
  • Q9UF60
sequenceLength 1419
species [Species:48887] Homo sapiens
stId uniprot:Q86US8
url http://purl.uniprot.org/uniprot/Q86US8
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