UniProt:Q86U86 PBRM1

chain
  • chain:1-1689
checksum 0A656E319C4FC748
comment
  • FUNCTION Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.SUBUNIT Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. Interacts with PHF10/BAF45A (By similarity). Interacts with acetylated 'Lys-14' of histone H3 (H3K14ac), and may also interact with other acetylated or methylated Lys residues on histone H3.INTERACTION Widely expressed.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Contaminating sequence.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 241877
description
  • recommendedName: Protein polybromo-1 shortName: hPB1 alternativeName: BRG1-associated factor 180 shortName: BAF180 alternativeName: Polybromo-1D
displayName UniProt:Q86U86 PBRM1
geneName
  • PBRM1
  • BAF180
  • PB1
identifier Q86U86
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Bromodomain
  • Chromatin regulator
  • DNA-binding
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Tumor suppressor
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • PBRM1
otherIdentifier
  • 11740171_s_at
  • 11744007_s_at
  • 11744956_a_at
  • 11746482_a_at
  • 16954856
  • 220355_PM_s_at
  • 220355_s_at
  • 221212_3p_x_at
  • 221212_PM_x_at
  • 221212_x_at
  • 223238_PM_s_at
  • 223238_s_at
  • 223400_3p_s_at
  • 223400_PM_s_at
  • 223400_s_at
  • 224152_PM_s_at
  • 224152_s_at
  • 2676218
  • 2676220
  • 2676221
  • 2676222
  • 2676223
  • 2676224
  • 2676226
  • 2676227
  • 2676232
  • 2676237
  • 2676239
  • 2676240
  • 2676241
  • 2676242
  • 2676243
  • 2676244
  • 2676245
  • 2676246
  • 2676247
  • 2676248
  • 2676251
  • 2676256
  • 2676257
  • 2676258
  • 2676259
  • 2676261
  • 2676262
  • 2676264
  • 2676268
  • 2676269
  • 2676271
  • 2676276
  • 2676277
  • 2676279
  • 2676282
  • 2676284
  • 2676286
  • 2676287
  • 2676288
  • 2676289
  • 2676292
  • 2676294
  • 2676295
  • 2676299
  • 2676300
  • 2676301
  • 2676302
  • 2676303
  • 2676304
  • 2676310
  • 2676312
  • 48990_at
  • 55193
  • 8087951
  • A_23_P218863
  • A_23_P365874
  • A_24_P362850
  • A_33_P3269578
  • A_33_P3330453
  • GE82345
  • GO:0000228
  • GO:0000278
  • GO:0000776
  • GO:0000785
  • GO:0003677
  • GO:0003682
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0006357
  • GO:0006368
  • GO:0008285
  • GO:0016363
  • GO:0016514
  • GO:0016586
  • GO:0030071
  • GO:0043226
  • GO:0045582
  • GO:0045597
  • GO:0045663
  • GO:0060999
  • GO:0070316
  • GO:2000045
  • GO:2000781
  • GO:2000819
  • HMNXSV003014810
  • Hs.44143.2.S2_3p_s_at
  • ILMN_1659470
  • ILMN_1723822
  • ILMN_2385239
  • PH_hs_0022841
  • TC03001457.hg
  • g11493428_3p_a_at
  • g12083895_3p_a_at
  • g8922564_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PB1_HUMAN
  • A1L381
  • A1L382
  • A4FUJ7
  • Q1RMD1
  • Q1RMD2
  • Q96MS2
  • Q9H2T3
  • Q9H2T4
  • Q9H2T5
  • Q9H301
  • Q9H314
sequenceLength 1689
species [Species:48887] Homo sapiens
stId uniprot:Q86U86
url http://purl.uniprot.org/uniprot/Q86U86
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