UniProt:Q86TX2 ACOT1

chain
  • initiator methionine:1
  • chain:2-421
checksum 04675F28D9D53B97
comment
  • FUNCTION Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)CATALYTIC ACTIVITY decanoyl-CoA + H2O = decanoate + CoA + H(+)CATALYTIC ACTIVITY dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)CATALYTIC ACTIVITY tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)CATALYTIC ACTIVITY octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)CATALYTIC ACTIVITY eicosanoyl-CoA + H2O = eicosanoate + CoA + H(+)CATALYTIC ACTIVITY (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)CATALYTIC ACTIVITY (9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)CATALYTIC ACTIVITY (9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)BIOPHYSICOCHEMICAL PROPERTIES Lipid metabolism; fatty acid metabolism.SUBUNIT Monomer.INTERACTION Belongs to the C/M/P thioester hydrolase family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 146071
description
  • recommendedName: fullName evidence="5"Acyl-coenzyme A thioesterase 1 shortName evidence="5"Acyl-CoA thioesterase 1 ecNumber evidence="2"3.1.2.- alternativeName: CTE-I alternativeName: CTE-Ib alternativeName: Inducible cytosolic acyl-coenzyme A thioester hydrolase alternativeName: Long chain acyl-CoA thioester hydrolase shortName: Long chain acyl-CoA hydrolase alternativeName: fullName evidence="5"Palmitoyl-coenzyme A thioesterase ecNumber evidence="2"3.1.2.2
displayName UniProt:Q86TX2 ACOT1
geneName
  • ACOT1
  • CTE1
identifier Q86TX2
isSequenceChanged false
keyword
  • Cytoplasm
  • Direct protein sequencing
  • Fatty acid metabolism
  • Hydrolase
  • Lipid metabolism
  • Proteomics identification
  • Reference proteome
  • Serine esterase
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • ACOT1
otherIdentifier
  • 11755310_s_at
  • 16786248
  • 202982_PM_s_at
  • 202982_s_at
  • 3543674
  • 3543675
  • 3543676
  • 3543682
  • 3543684
  • 3543685
  • 3543686
  • 3543687
  • 3543688
  • 3543699
  • 3543707
  • 3543708
  • 3543709
  • 3543710
  • 36625_at
  • 641371
  • 7975598
  • A_24_P161036
  • GO:0000038
  • GO:0001676
  • GO:0003824
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0006629
  • GO:0006631
  • GO:0006637
  • GO:0006790
  • GO:0016787
  • GO:0016790
  • GO:0032787
  • GO:0047617
  • GO:0052689
  • GO:0055086
  • HMNXSV003015640
  • ILMN_1715543
  • ILMN_2121389
  • L40401_at
  • PH_hs_0027480
  • TC14002199.hg
  • g13375613_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ACOT1_HUMAN
  • A1L173
  • Q3I5F9
sequenceLength 421
species [Species:48887] Homo sapiens
stId uniprot:Q86TX2
url http://purl.uniprot.org/uniprot/Q86TX2
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