UniProt:Q7Z6A9 BTLA

chain
  • signal peptide:1-30
  • chain:31-289
checksum F4D1FF775D7D33F3
comment
  • FUNCTION Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).SUBUNIT Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). Interacts with TNFRSF14/HVEM (via cysteine-rich domain 1) (PubMed:15568026, PubMed:18193050, PubMed:19915044).INTERACTION Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.PTM N-glycosylated.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:197786] de Bono, B, 2007-05-15 13:07:42
crossReference
databaseName UniProt
dbId 197767
description
  • recommendedName: fullName evidence="14 16"B- and T-lymphocyte attenuator alternativeName: B- and T-lymphocyte-associated protein cdAntigenNameCD272/cdAntigenName
displayName UniProt:Q7Z6A9 BTLA
geneName
  • BTLA
identifier Q7Z6A9
isSequenceChanged false
keyword
  • 3D-structure
  • Adaptive immunity
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Immunity
  • Immunoglobulin domain
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • BTLA
otherIdentifier
  • 11735221_a_at
  • 11735222_a_at
  • 151888
  • 16957363
  • 236226_PM_at
  • 236226_at
  • 2688724
  • 2688725
  • 2688726
  • 2688727
  • 2688728
  • 2688729
  • 2688731
  • 2688732
  • 2688733
  • 2688735
  • 2688738
  • 2688739
  • 2688740
  • 59046_at
  • 8089519
  • A_23_P80883
  • A_33_P3358923
  • GE511776
  • GO:0002250
  • GO:0002376
  • GO:0002768
  • GO:0005515
  • GO:0005886
  • GO:0016020
  • GO:0038023
  • GO:0042130
  • HMNXSV003010191
  • Hs.126808.0.A1_3p_at
  • ILMN_1778536
  • ILMN_2099528
  • PH_hs_0036038
  • TC03001649.hg
  • TC03003026.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BTLA_HUMAN
  • Q3B831
  • Q3HS85
  • Q6ZNH9
sequenceLength 289
species [Species:48887] Homo sapiens
stId uniprot:Q7Z6A9
url http://purl.uniprot.org/uniprot/Q7Z6A9
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