UniProt:Q70EL4 USP43

chain
  • chain:1-1123
checksum 3B4FE86EC619173C
comment
  • FUNCTION May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).CATALYTIC ACTIVITY Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ALTERNATIVE PRODUCTS Expressed in brain, aorta and lung at low levels.SIMILARITY Belongs to the peptidase C19 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 253621
description
  • recommendedName: Ubiquitin carboxyl-terminal hydrolase 43 ecNumber: 3.4.19.12 alternativeName: Deubiquitinating enzyme 43 alternativeName: Ubiquitin thioesterase 43 alternativeName: Ubiquitin-specific-processing protease 43
displayName UniProt:Q70EL4 USP43
geneName
  • USP43
identifier Q70EL4
isSequenceChanged false
keyword
  • Alternative splicing
  • Hydrolase
  • Methylation
  • Phosphoprotein
  • Protease
  • Proteomics identification
  • Reference proteome
  • Thiol protease
  • Ubl conjugation pathway
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • USP43
otherIdentifier
  • 11730582_a_at
  • 11755398_a_at
  • 124739
  • 16831046
  • 237439_PM_at
  • 237439_at
  • 3710051
  • 3710052
  • 3710053
  • 3710054
  • 3710057
  • 3710058
  • 3710059
  • 3710063
  • 3710064
  • 3710065
  • 3710066
  • 3710068
  • 3710071
  • 3710074
  • 3710075
  • 3710076
  • 3710077
  • 3710078
  • 3710079
  • 3710080
  • 3710081
  • 3710084
  • 3710085
  • 3710087
  • 3710088
  • 3710089
  • 3710090
  • 3710091
  • 3710092
  • 3710093
  • 3710094
  • 3710095
  • 3710096
  • 8004905
  • A_24_P310009
  • GE557971
  • GO:0004843
  • GO:0005634
  • GO:0005654
  • GO:0006281
  • GO:0006508
  • GO:0008233
  • GO:0008234
  • GO:0016579
  • GO:0016787
  • GO:0019783
  • GO:0019785
  • GO:0019985
  • HMNXSV003013928
  • Hs.23935.0.A1_3p_at
  • ILMN_2093188
  • PH_hs_0002106
  • TC17000146.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • UBP43_HUMAN
  • A6NDT9
  • B7ZLT9
  • B7ZVX5
  • Q8N2C5
  • Q96DQ6
sequenceLength 1123
species [Species:48887] Homo sapiens
stId uniprot:Q70EL4
url http://purl.uniprot.org/uniprot/Q70EL4
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