UniProt:Q6ZWT7 MBOAT2

chain
  • chain:1-520
checksum 27FFC44815B21288
comment
  • FUNCTION Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity).CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoACATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoACATALYTIC ACTIVITY (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoACATALYTIC ACTIVITY 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoACATALYTIC ACTIVITY 1-octadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoAACTIVITY REGULATION Partially inhibited by thimerosal.PATHWAY Lipid metabolism; phospholipid metabolism.SUBCELLULAR LOCATION Expressed in neutrophils.SIMILARITY Belongs to the membrane-bound acyltransferase family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 236780
description
  • recommendedName: fullName evidence="6"Membrane-bound glycerophospholipid O-acyltransferase 2 ecNumber evidence="4"2.3.1.- alternativeName: fullName evidence="5"1-acylglycerophosphate O-acyltransferase MBOAT2 ecNumber evidence="4"2.3.1.51 alternativeName: fullName evidence="5"1-acylglycerophosphocholine O-acyltransferase MBOAT2 ecNumber evidence="4"2.3.1.23 alternativeName: fullName evidence="5"1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase ecNumber evidence="4"2.3.1.n7 alternativeName: Lysophosphatidic acid acyltransferase shortName: LPAAT shortName: Lyso-PA acyltransferase alternativeName: Lysophosphatidylcholine acyltransferase shortName: LPCAT shortName: Lyso-PC acyltransferase alternativeName: Lysophosphatidylcholine acyltransferase 4 shortName: Lyso-PC acyltransferase 4 alternativeName: Lysophosphatidylethanolamine acyltransferase shortName: LPEAT shortName: Lyso-PE acyltransferase alternativeName: fullName evidence="5"Lysophospholipid acyltransferase 2 shortName: LPLAT 2 alternativeName: Membrane-bound O-acyltransferase domain-containing protein 2 shortName: O-acyltransferase domain-containing protein 2
displayName UniProt:Q6ZWT7 MBOAT2
geneName
  • MBOAT2
  • LPCAT4
  • OACT2
identifier Q6ZWT7
isSequenceChanged false
keyword
  • Acyltransferase
  • Endoplasmic reticulum
  • Lipid biosynthesis
  • Lipid metabolism
  • Membrane
  • Phospholipid biosynthesis
  • Phospholipid metabolism
  • Proteomics identification
  • Reference proteome
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • MBOAT2
otherIdentifier
  • 11730900_s_at
  • 11730901_at
  • 11751377_a_at
  • 129642
  • 16894283
  • 213288_PM_at
  • 213288_at
  • 226726_PM_at
  • 226726_at
  • 2539604
  • 2539606
  • 2539608
  • 2539609
  • 2539610
  • 2539611
  • 2539612
  • 2539613
  • 2539614
  • 2539615
  • 2539616
  • 2539617
  • 2539618
  • 2539619
  • 2539621
  • 2539622
  • 2539623
  • 2539624
  • 2539626
  • 2539631
  • 2539632
  • 2539643
  • 2539650
  • 2539663
  • 2539664
  • 38262_at
  • 42065_at
  • 58288_at
  • 78009_r_at
  • 8050160
  • A_23_P370635
  • A_24_P114255
  • A_32_P119096
  • GE517106
  • GE54448
  • GO:0003841
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0006644
  • GO:0008654
  • GO:0016020
  • GO:0016740
  • GO:0016746
  • GO:0030258
  • GO:0032330
  • GO:0036150
  • GO:0036151
  • GO:0036152
  • GO:0047144
  • GO:0047184
  • GO:0106262
  • GO:0106263
  • HMNXSV003032543
  • Hs.15641.0.A1_3p_at
  • Hs.15641.0.A1_3p_x_at
  • Hs.90797.0.S1_3p_at
  • ILMN_1777853
  • ILMN_2347424
  • PH_hs_0022207
  • TC02001556.hg
  • TC02004035.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MBOA2_HUMAN
  • A9EDR2
  • Q8NCE7
  • Q96KY4
sequenceLength 520
species [Species:48887] Homo sapiens
stId uniprot:Q6ZWT7
url http://purl.uniprot.org/uniprot/Q6ZWT7
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