Reactome | UniProt:Q6ZWR6 Syne1

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UniProt:Q6ZWR6 Syne1 Show undefined attributes

chain	chain:1-8799
checksum	2A457DC081969CF0
comment	FUNCTION Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.SUBUNIT Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. The SUN2:SYNE1/KASH1 LINC complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE1/KASH1 peptides bind at the interface of adjacent SUN domains. Self-associates. Interacts with SYNE3. Interacts with SUN3; proposed to form a spermatogenesis-specific LINC complex with SUN3 during sperm head formation. May interact with MUSK. Interacts with SPAG4/SUN4. Interacts with EMD and LMNA in vitro. Interacts with F-actin via its N-terminal domain. Interacts with DCTN1 and DYNC1I1/2; suggesting the association with the dynein-dynactin motor complex. Interacts (via KASH domain) with TMEM258 (By similarity).INTERACTION The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. In skeletal and smooth muscles, a significant amount is found in the sarcomeres (By similarity).ALTERNATIVE PRODUCTS Expressed in C2F3 and CH310T1/2 cells, brain and skeletal muscle (at protein level).DOMAIN The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.PTM The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.MISCELLANEOUS Incomplete sequence.SIMILARITY Belongs to the nesprin family.
created	[InstanceEdit:613449] Kanapin, AA
crossReference	[DatabaseIdentifier:12414863] RefSeq:NP_071310.2 [DatabaseIdentifier:12414865] RefSeq:XP_036011830.1 [DatabaseIdentifier:12414864] RefSeq:NP_700448.2 [DatabaseIdentifier:12414866] RefSeq:NP_001073154.1 [DatabaseIdentifier:12245674] PRO:Q6ZWR6 [DatabaseIdentifier:11935393] MGI:1927152 [DatabaseIdentifier:11803532] GlyGen:Q6ZWR6 [DatabaseIdentifier:11723398] ENSEMBL:ENSMUST00000041639 [DatabaseIdentifier:11723397] ENSEMBL:ENSMUST00000095899 [DatabaseIdentifier:11600698] ENSEMBL:ENSMUSP00000093587 [DatabaseIdentifier:11600699] ENSEMBL:ENSMUSP00000039440 [DatabaseIdentifier:11493288] ENSEMBL:ENSMUSG00000096054
databaseName	UniProt
dbId	613627
description	recommendedName: fullName evidence="17"Nesprin-1 alternativeName: Enaptin alternativeName: KASH domain-containing protein 1 shortName: KASH1 alternativeName: Myocyte nuclear envelope protein 1 shortName: Myne-1 alternativeName: Nuclear envelope spectrin repeat protein 1 alternativeName: Synaptic nuclear envelope protein 1 shortName: Syne-1
displayName	UniProt:Q6ZWR6 Syne1
geneName	Syne1
identifier	Q6ZWR6
isSequenceChanged	false
keyword	Actin-binding Alternative splicing Coiled coil Cytoplasm Cytoskeleton Differentiation Disulfide bond Membrane Nucleus Phosphoprotein Reference proteome Repeat Spermatogenesis Transmembrane Transmembrane helix
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Syne1
otherIdentifier	10361381 10361509 110221_at 117157_at 140838_at 1421545_a_at 1455225_at 1455493_at 17238762 17238824 17238826 17238828 17238830 17238832 17238834 17238836 17238838 17238840 17238842 17238844 17238846 17238848 17238850 17238852 17238854 17238856 17238858 17238860 17238862 17238864 17238866 17238868 17238870 17238872 17238874 17238876 17238878 17238880 17238882 17238884 17238886 17238888 17238890 17238892 17238894 17238896 17238898 17238900 17238902 17238904 17238906 17238908 17238910 17238912 17238914 17238916 17238918 17238920 17238922 17238924 17238926 17238928 17238930 17238932 17238934 17238936 17238938 4385227 4386985 4389520 4399459 4400247 4406766 4411740 4433583 4441443 4449589 4458449 4460735 4478355 4478619 4479428 4479984 4491480 4498554 4501350 4527380 4529049 4529801 4543219 4545245 4549772 4552243 4556345 4560659 4564300 4567048 4574604 4578253 4584022 4584878 4598857 4599315 4641579 4644298 4644676 4650166 4653697 4660960 4666895 4670054 4674605 4676983 4682935 4689230 4696874 4711110 4725379 4743040 4750431 4750707 4750745 4754357 4760770 4766931 4771556 4777846 4780281 4783876 4784146 4795004 4795489 4797718 4814058 4815833 4832304 4838135 4855388 4871626 4890181 4891623 4893699 4905333 4925944 4941220 4960296 4962400 4965993 4968591 4968745 4974979 4984869 4990884 4992068 4992591 4993510 4998840 5004823 5010844 5012593 5035759 5039975 5055002 5064049 5084435 5087146 5093108 5103434 5115740 5119244 5128019 5137421 5146636 5152091 5153284 5158508 5165567 5190031 5190787 5194183 5195054 5203608 5204515 5204848 5209869 5212348 5221753 5226081 5238955 5244217 5246991 5263367 5265177 5267590 5278800 5284875 5290424 5298088 5300623 5308090 5324803 5335970 5342600 5346095 5349666 5353754 5361890 5362035 5380956 5395110 5442882 5447050 5448434 5451836 5458110 5468475 5468481 5470765 5476867 5485831 5487972 5491529 5494254 5501468 5507213 5517898 5527966 5528180 5530046 5531931 5531990 5539296 5563543 5564118 5573723 5591542 5593300 5603885 5607529 5614554 5614635 64009 A_51_P305777 A_51_P314186 A_52_P306162 A_52_P335984 A_52_P453864 A_55_P2026295 A_55_P2736215 GE1548578 GO:0000932 GO:0003779 GO:0005515 GO:0005521 GO:0005634 GO:0005635 GO:0005640 GO:0005654 GO:0005730 GO:0005737 GO:0005794 GO:0005856 GO:0007030 GO:0007097 GO:0007283 GO:0008092 GO:0016020 GO:0019899 GO:0022414 GO:0030017 GO:0030154 GO:0031965 GO:0034993 GO:0042692 GO:0042802 GO:0042803 GO:0043226 GO:0045211 GO:0051015 GO:0051642 GO:0090292 GO:0140444 GO:1902017 ILMN_1219831 ILMN_1229769 ILMN_1245366 ILMN_1248614 ILMN_1249542 ILMN_1252327 ILMN_2636200 ILMN_3017615 ILMN_3028463 ILMN_3049961 mMR029913
physicalEntity	[EntityWithAccessionedSequence:R-MMU-912388] Syne1 [nuclear envelope] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12751836] UCSC:Q6ZWR6 Syne1 [ReferenceDNASequence:12072761] NCBI Gene:64009 Syne1 [ReferenceDNASequence:11988668] Monarch:64009 Syne1 [ReferenceDNASequence:11898071] KEGG:mmu:64009 Syne1 [ReferenceDNASequence:11358879] BioGPS Gene:64009 Syne1
referenceTranscript	[ReferenceRNASequence:12596563] RefSeq:NM_001079686.1 Syne1 [ReferenceRNASequence:12596564] RefSeq:XM_036155937.1 Syne1 [ReferenceRNASequence:12596561] RefSeq:NM_022027.3 Syne1 [ReferenceRNASequence:12596562] RefSeq:NM_153399.3 Syne1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SYNE1_MOUSE Q8K3T7 Q9ERT7 Q9ERT8
sequenceLength	8799
species	[Species:48892] Mus musculus
stId	uniprot:Q6ZWR6
url	http://purl.uniprot.org/uniprot/Q6ZWR6

Referrals

(interactor)	[UndirectedInteraction:11267585] UniProt:Q6ZWR6 <-> UniProt:Q9JJF2 (IntAct) [UndirectedInteraction:11267581] UniProt:Q6ZWR6 <-> UniProt:Q5SS91 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-912388] Syne1 [nuclear envelope]

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