UniProt:Q6ZUV0 ACOT7L

chain
  • chain:1-252
checksum E9C4DF4A82B87717
comment
  • FUNCTION Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)SUBUNIT Homodimer.SUBCELLULAR LOCATION Expressed in all tissues examined. Up-regulated in nasopharyngeal carcinoma (at protein level).DISEASE A functional variant in the transcriptional regulatory region of in ACOT7L cosegregates with disease phenotype in family affected by nasopharyngeal carcinoma. The variant creates an AP1-binding site that significantly enhances binding of AP1 to the promoter, resulting in up-regulation.CAUTION Could be the product of a pseudogene. The peptide used to produce antibodies against ACOT7L matches at 85% with ACOT7 and the antibodies may not be specific to ACOT7L.
created [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
crossReference
databaseName UniProt
dbId 384515
description
  • recommendedName: Putative cytosolic acyl coenzyme A thioester hydrolase-like ecNumber: 3.1.2.2 alternativeName: Acyl-CoA thioesterase 7-like
displayName UniProt:Q6ZUV0 ACOT7L
geneName
  • ACOT7L
  • BACHL
identifier Q6ZUV0
isSequenceChanged false
keyword
  • Cytoplasm
  • Hydrolase
  • Lipid metabolism
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Serine esterase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • ACOT7L
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BACHL_HUMAN
sequenceLength 252
species [Species:48887] Homo sapiens
stId uniprot:Q6ZUV0
url http://purl.uniprot.org/uniprot/Q6ZUV0
Cite Us!