UniProt:Q6ZN44 UNC5A

chain
  • signal peptide:1-25
  • chain:26-842
checksum 7B209042977FE524
comment
  • FUNCTION Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.SUBUNIT Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).SUBCELLULAR LOCATION The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones.ALTERNATIVE PRODUCTS By p53/TP53.DOMAIN The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.PTM Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).PTM Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.PTM The two extracellular TSRs of UNC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans. DPY19L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third. C-mannosylation by DPY19L1 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface.MISCELLANEOUS Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.SIMILARITY Belongs to the unc-5 family.SEQUENCE CAUTION Intron retention.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 155547
description
  • recommendedName: Netrin receptor UNC5A alternativeName: Protein unc-5 homolog 1 alternativeName: Protein unc-5 homolog A
displayName UniProt:Q6ZN44 UNC5A
geneName
  • UNC5A
  • KIAA1976
  • UNC5H1
identifier Q6ZN44
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Cell membrane
  • Cell projection
  • Developmental protein
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • UNC5A
otherIdentifier
  • 11730490_at
  • 16992918
  • 236448_PM_at
  • 236448_at
  • 2842787
  • 2842789
  • 2842791
  • 2842793
  • 2842795
  • 2842797
  • 2842799
  • 2842801
  • 2842803
  • 2842805
  • 2842807
  • 2842819
  • 2842821
  • 2842823
  • 2842825
  • 2842827
  • 2842829
  • 2842835
  • 2842837
  • 2842839
  • 2842841
  • 2842843
  • 2842845
  • 2842847
  • 47437_at
  • 8110237
  • 88651_at
  • 90249
  • A_23_P110557
  • A_33_P3379001
  • GO:0005042
  • GO:0005515
  • GO:0005886
  • GO:0006915
  • GO:0007165
  • GO:0016020
  • GO:0031175
  • GO:0032589
  • GO:0032809
  • GO:0033564
  • GO:0038007
  • GO:0042995
  • GO:0043005
  • GO:0045121
  • HMNXSV003043676
  • Hs.119486.0.A1_3p_at
  • ILMN_1712913
  • PH_hs_0002789
  • TC05001007.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • UNC5A_HUMAN
  • B2RXE6
  • Q8TF26
  • Q96GP4
sequenceLength 842
species [Species:48887] Homo sapiens
stId uniprot:Q6ZN44
url http://purl.uniprot.org/uniprot/Q6ZN44
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