UniProt:Q6UXT8 ALKAL1

chain
  • signal peptide:1-27
  • chain:28-129
checksum 8B4F6D7B5679B4E2
comment
  • FUNCTION Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation (PubMed:25331893, PubMed:26418745, PubMed:26630010, PubMed:34646012, PubMed:34819673). Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation (PubMed:34646012, PubMed:34819673). In contrast to ALKAL2, does not act as a potent physiological ligand for ALK (PubMed:26418745, PubMed:34646012).INTERACTION Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK.ALTERNATIVE PRODUCTS Widely expressed with highest levels in thyroid and moderate levels in stomach, trachea, small intestine, prostate and brain.SIMILARITY Belongs to the ALKAL family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228868
description
  • recommendedName: fullName evidence="13 14"ALK and LTK ligand 1 alternativeName: fullName evidence="12"Augmentor beta shortName evidence="12"AUG-beta
displayName UniProt:Q6UXT8 ALKAL1
geneName
  • ALKAL1
  • FAM150A
  • UNQ9433/PRO34745
identifier Q6UXT8
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cytokine
  • Disulfide bond
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • ALKAL1
otherIdentifier
  • 11737645_a_at
  • 17077128
  • 3135170
  • 3135171
  • 3135172
  • 3135174
  • 3135181
  • 3135182
  • 389658
  • 8150751
  • A_24_P935794
  • GO:0005125
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005886
  • GO:0007169
  • GO:0010976
  • GO:0016020
  • GO:0030297
  • GO:0030298
  • GO:0030971
  • GO:0048018
  • GO:0070374
  • GO:0070378
  • GO:0098772
  • HMNXSV003026998
  • ILMN_1753933
  • ILMN_2091217
  • PH_hs_0034586
  • TC08001209.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ALKL1_HUMAN
  • B7ZMG9
sequenceLength 129
species [Species:48887] Homo sapiens
stId uniprot:Q6UXT8
url http://purl.uniprot.org/uniprot/Q6UXT8
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