UniProt:Q6SW59 UL83

chain
  • chain:1-561
checksum 134FD1500DE40B32
comment
  • FUNCTION Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus. Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1. Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.SUBUNIT Interacts with host NCL/nucleolin. Interacts with host IFI16. Interacts with host CGAS; this interaction inhibits CGAS enzymatic activity.SUBCELLULAR LOCATION As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection. The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection. Thereafter, pp65 is probably exported and accumulates in the cytoplasm. Also found in dense bodies.PTM Phosphorylation may play a role in the localization of the protein.SIMILARITY Belongs to the herpesviridae pp65 family.
created [InstanceEdit:9037922] Gillespie, Marc E, 2018-02-21
crossReference
databaseName UniProt
dbId 9037915
description
  • recommendedName: 65 kDa phosphoprotein shortName: pp65 alternativeName: 65 kDa matrix phosphoprotein alternativeName: Phosphoprotein UL83 alternativeName: Tegument protein UL83
displayName UniProt:Q6SW59 UL83
geneName
  • UL83
identifier Q6SW59
isSequenceChanged false
keyword
  • 3D-structure
  • Host cytoplasm
  • Host nucleus
  • Host-virus interaction
  • Inhibition of host innate immune response by virus
  • Inhibition of host IRF3 by virus
  • Inhibition of host RLR pathway by virus
  • Phosphoprotein
  • Reference proteome
  • Viral immunoevasion
  • Virion
  • Virion tegument
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • UL83
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PP65_HCMVM
  • D2K3P1
sequenceLength 561
species [Species:2671791] Human cytomegalovirus
stId uniprot:Q6SW59
url http://purl.uniprot.org/uniprot/Q6SW59
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