Reactome | UniProt:Q6PDQ2 Chd4

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UniProt:Q6PDQ2 Chd4 Show undefined attributes

chain	chain:1-1915
checksum	CFCB83B419AE6B5A
comment	FUNCTION ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:17938210). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (By similarity). Involved in neurogenesis (PubMed:27806305).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:27806305). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:27806305). Interacts with IKFZ1; the interaction is direct and when in part of the NuRD complex (PubMed:11003653). Part of a complex containing ATR and HDAC2 (By similarity). Interacts with HDAC2; the interaction is direct (PubMed:27806305). Interacts with the cohesin complex component RAD21; the interaction is direct (By similarity). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (By similarity). Interacts with ZGPAT; the interaction is direct (By similarity). Interacts with ZMYND8; the interaction is direct, appears to occur with monomeric ZMYND8, and is increased following DNA damage (By similarity). Interacts with BCL6 (By similarity). Interacts with BRD4 (By similarity). Interacts with CBX1 (By similarity). Interacts with CBX3 (By similarity). Interacts with CBX5 (By similarity). Interacts with GATAD2A (By similarity). Interacts with HDAC1 (By similarity). Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (PubMed:17938210). Interacts with MTA1 (By similarity). Interacts with PCNT (By similarity). Interacts with RBBP7 (By similarity). Interacts with SETX (By similarity). Interacts with TRIM27 (By similarity). Interacts with histone H3 (By similarity). Interacts with histone H4 (By similarity). Does not interact with PWWP2A (PubMed:30228260, PubMed:30327463). Does not interact with PWWP2B (PubMed:30228260). Interacts (via KIKL motif) with BRD3 (via NET domain) (By similarity).INTERACTION Associates with centrosomes in interphase. Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687.DEVELOPMENTAL STAGE Expression is constant from 12.5 dpc to 18.5 dpc in the cortex.DOMAIN The KIKL motif recognizes and binds the NET domain of BRD3.SIMILARITY Belongs to the SNF2/RAD54 helicase family.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:12341280] RefSeq:NP_001333539.1 [DatabaseIdentifier:12341281] RefSeq:NP_001390527.1 [DatabaseIdentifier:12253885] PRO:Q6PDQ2 [DatabaseIdentifier:11934046] MGI:1344380 [DatabaseIdentifier:11809920] GlyGen:Q6PDQ2 [DatabaseIdentifier:11676007] ENSEMBL:ENSMUST00000056889 [DatabaseIdentifier:11553308] ENSEMBL:ENSMUSP00000060054 [DatabaseIdentifier:11460481] ENSEMBL:ENSMUSG00000063870
databaseName	UniProt
dbId	145374
description	recommendedName: fullName evidence="14"ATP-dependent chromatin remodeler CHD4 ecNumber evidence="3"3.6.4.- alternativeName: fullName evidence="14"Chromo domain-containing protein 4 shortName: CHD-4
displayName	UniProt:Q6PDQ2 Chd4
geneName	Chd4
identifier	Q6PDQ2
isSequenceChanged	false
keyword	Acetylation ATP-binding Chromatin regulator Cytoplasm Cytoskeleton DNA-binding Hydrolase Isopeptide bond Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	Chd4
otherIdentifier	10541803 107932 108356_at 1436343_at 1438476_a_at 1451295_a_at 17463056 17463106 4307214 4328161 4341156 4357734 4367740 4413959 4426381 4454223 4457794 4537658 4558136 4636567 4644159 4667603 4694524 4743273 4765975 4770716 4795873 4799646 4854933 4874371 4880059 4906600 4917312 5042299 5059848 5078917 5117569 5131719 5206281 5245196 5247037 5248708 5277425 5304507 5340703 5343019 5349657 5364989 5368041 5403895 5417253 5435352 5456678 5477710 5496800 5550480 5562867 5573240 5596602 5614102 99120_f_at AA617397_rc_s_at A_51_P454280 A_52_P298043 A_52_P58281 A_55_P2020373 GE102250 GO:0000122 GO:0000166 GO:0000724 GO:0000781 GO:0000785 GO:0001221 GO:0003677 GO:0003682 GO:0003714 GO:0003824 GO:0004386 GO:0005515 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005813 GO:0005815 GO:0005856 GO:0006281 GO:0006310 GO:0006325 GO:0006338 GO:0006355 GO:0008270 GO:0010629 GO:0015671 GO:0016581 GO:0016787 GO:0016887 GO:0032991 GO:0032993 GO:0042393 GO:0042659 GO:0042826 GO:0045892 GO:0045893 GO:0046872 GO:0051963 GO:0061629 GO:0072553 GO:0090575 GO:0090734 GO:0140097 GO:0140297 GO:0140657 GO:0140658 GO:0150048 GO:2000736 ILMN_1236358 ILMN_1256696 ILMN_2654822 ILMN_2697652 Msa.8530.0_f_at R75450_rc_s_at mMC010596 mMC022759 mMR029264
physicalEntity	[EntityWithAccessionedSequence:R-MMU-5096464] Chd4 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-3702078] CHD4 [nucleoplasm] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12731185] UCSC:Q6PDQ2 Chd4 [ReferenceDNASequence:12038946] NCBI Gene:107932 Chd4 [ReferenceDNASequence:11954853] Monarch:107932 Chd4 [ReferenceDNASequence:11867501] KEGG:mmu:107932 Chd4 [ReferenceDNASequence:11325064] BioGPS Gene:107932 Chd4
referenceTranscript	[ReferenceRNASequence:12523154] RefSeq:NM_001403598.1 Chd4 [ReferenceRNASequence:12523153] RefSeq:NM_001346610.2 Chd4
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CHD4_MOUSE
sequenceLength	1915
species	[Species:48892] Mus musculus
stId	uniprot:Q6PDQ2
url	http://purl.uniprot.org/uniprot/Q6PDQ2

Referrals

(interactor)	[UndirectedInteraction:11164411] UniProt:Q6PDQ2 <-> UniProt:P70326 (IntAct) [UndirectedInteraction:11164409] UniProt:Q6PDQ2 <-> UniProt:Q9R190 (IntAct) [UndirectedInteraction:11164407] UniProt:Q6PDQ2 <-> UniProt:Q80V81 (IntAct) [UndirectedInteraction:11164405] UniProt:Q6PDQ2 <-> UniProt:Q60I23 (IntAct) [UndirectedInteraction:11164403] UniProt:Q6PDQ2 <-> UniProt:P20263 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-5096464] Chd4 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-3702078] CHD4 [nucleoplasm]

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