UniProt:Q6PCB6 ABHD17C

chain
  • chain:1-329
checksum A5EE8ED4291EC49F
comment
  • FUNCTION Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.CATALYTIC ACTIVITY S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)ACTIVITY REGULATION Inhibited by palmostatin-B.INTERACTION Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.SIMILARITY Belongs to the AB hydrolase superfamily. ABHD17 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228683
description
  • recommendedName: fullName evidence="8"Alpha/beta hydrolase domain-containing protein 17C shortName evidence="9"Abhydrolase domain-containing protein 17C ecNumber evidence="6"3.1.2.22
displayName UniProt:Q6PCB6 ABHD17C
geneName
  • ABHD17C
  • FAM108C1
identifier Q6PCB6
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Endosome
  • Hydrolase
  • Lipoprotein
  • Membrane
  • Palmitate
  • Postsynaptic cell membrane
  • Proteomics identification
  • Reference proteome
  • Synapse
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • ABHD17C
otherIdentifier
  • 11726050_a_at
  • 11752456_a_at
  • 11758217_s_at
  • 16803743
  • 225436_PM_at
  • 225436_at
  • 3604120
  • 3604121
  • 3604122
  • 3604123
  • 3604124
  • 3604125
  • 3604127
  • 3604129
  • 3604134
  • 3604137
  • 3604138
  • 3604139
  • 3604140
  • 3604142
  • 44115_at
  • 58489
  • 7985310
  • A_14_P118049
  • A_23_P369701
  • A_32_P39093
  • GE86060
  • GO:0002084
  • GO:0003824
  • GO:0005515
  • GO:0005768
  • GO:0005886
  • GO:0008474
  • GO:0010008
  • GO:0014069
  • GO:0016020
  • GO:0016787
  • GO:0030163
  • GO:0042995
  • GO:0043197
  • GO:0043226
  • GO:0045202
  • GO:0045211
  • GO:0055038
  • GO:0098839
  • GO:0098978
  • GO:0099175
  • GO:0140096
  • GO:1902817
  • GO:1905668
  • HMNXSV003017758
  • Hs.26765.0.S1_3p_at
  • ILMN_1788416
  • PH_hs_0002364
  • TC15000751.hg
  • p33780
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AB17C_HUMAN
  • Q1RMD6
  • Q9NPM1
sequenceLength 329
species [Species:48887] Homo sapiens
stId uniprot:Q6PCB6
url http://purl.uniprot.org/uniprot/Q6PCB6
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