Reactome | UniProt:Q6P4R8 NFRKB

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UniProt:Q6P4R8 NFRKB Show undefined attributes

chain	chain:1-1299
checksum	087B212E283C3820
comment	FUNCTION Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.FUNCTION Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.SUBUNIT Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5.INTERACTION Expressed in thymus, brain, testes, spleen and liver.DOMAIN NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA.SIMILARITY Belongs to the NFRKB family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12318945] RefSeq:NP_001137307.1 [DatabaseIdentifier:12318946] RefSeq:NP_006156.2 [DatabaseIdentifier:12284616] Pharos - Targets:Q6P4R8 [DatabaseIdentifier:12244035] PRO:Q6P4R8 [DatabaseIdentifier:12172091] PDB:3U21 [DatabaseIdentifier:12146703] PDB:4UF5 [DatabaseIdentifier:12146707] PDB:4WLP [DatabaseIdentifier:12146704] PDB:4UF6 [DatabaseIdentifier:12124304] OpenTargets:ENSG00000170322 [DatabaseIdentifier:11839776] HPA:ENSG00000170322-NFRKB [DatabaseIdentifier:11802172] GlyGen:Q6P4R8 [DatabaseIdentifier:11786697] GeneCards:NFRKB [DatabaseIdentifier:11660535] ENSEMBL:ENST00000524794 [DatabaseIdentifier:11660537] ENSEMBL:ENST00000446488 [DatabaseIdentifier:11660536] ENSEMBL:ENST00000682444 [DatabaseIdentifier:11660538] ENSEMBL:ENST00000524746 [DatabaseIdentifier:11537836] ENSEMBL:ENSP00000433572 [DatabaseIdentifier:11537837] ENSEMBL:ENSP00000506850 [DatabaseIdentifier:11537839] ENSEMBL:ENSP00000436926 [DatabaseIdentifier:11537838] ENSEMBL:ENSP00000400476 [DatabaseIdentifier:11449236] ENSEMBL:ENSG00000170322
databaseName	UniProt
dbId	239516
description	recommendedName: Nuclear factor related to kappa-B-binding protein alternativeName: DNA-binding protein R kappa-B alternativeName: INO80 complex subunit G
displayName	UniProt:Q6P4R8 NFRKB
geneName	NFRKB INO80G
identifier	Q6P4R8
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing DNA damage DNA recombination DNA repair DNA-binding Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NFRKB
otherIdentifier	11722268_a_at 11740706_a_at 16746104 206968_PM_s_at 206968_s_at 213028_PM_at 213028_at 237209_PM_s_at 237209_s_at 237210_PM_at 237210_at 3398080 3398081 3398082 3398083 3398084 3398085 3398086 3398087 3398091 3398092 3398094 3398096 3398097 3398098 3398099 3398100 3398101 3398102 3398103 3398105 3398106 3398110 3398111 3398112 3398113 3398114 3398115 3398116 3398117 3398119 3398120 3398121 3398122 3398123 3398124 3398125 3398126 3398127 3398128 3398129 3398131 3398132 3398133 3398136 3398137 3398138 3398139 3398140 3398141 3398142 39137_at 39138_g_at 4798 59476_at 7952677 82589_at A_23_P24485 GE58896 GO:0000723 GO:0002020 GO:0003677 GO:0005515 GO:0005634 GO:0005654 GO:0006275 GO:0006281 GO:0006282 GO:0006310 GO:0006325 GO:0006338 GO:0006355 GO:0006974 GO:0010604 GO:0031011 GO:0032200 GO:0033044 GO:0045739 GO:0045893 GO:0045935 GO:0045995 GO:0051052 GO:0051726 GO:0060382 GO:1904507 HMNXSV003032411 Hs.167006.0.A1_3p_at Hs.282441.1.S1_3p_at ILMN_1718990 TC11002448.hg U08191_s_at X80878_at g5453777_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5689578] NFRKB [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12724433] UCSC:Q6P4R8 NFRKB [ReferenceDNASequence:12109721] OMIM:164013 NFRKB [ReferenceDNASequence:12028652] NCBI Gene:4798 NFRKB [ReferenceDNASequence:11944559] Monarch:4798 NFRKB [ReferenceDNASequence:11858226] KEGG:hsa:4798 NFRKB [ReferenceDNASequence:11818336] HGNC:7802 NFRKB [ReferenceDNASequence:11434443] dbSNP Gene:4798 NFRKB [ReferenceDNASequence:11411948] CTD Gene:4798 NFRKB [ReferenceDNASequence:11397706] COSMIC - genes:NFRKB NFRKB [ReferenceDNASequence:11314770] BioGPS Gene:4798 NFRKB [ReferenceDNASequence:ensembl:ENSG00000170322] ENSEMBL:ENSG00000170322 NFRKB
referenceTranscript	[ReferenceRNASequence:12500947] RefSeq:NM_006165.3 NFRKB [ReferenceRNASequence:12500948] RefSeq:NM_001143835.2 NFRKB
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NFRKB_HUMAN Q12869 Q15312 Q9H048
sequenceLength	1299
species	[Species:48887] Homo sapiens
stId	uniprot:Q6P4R8
url	http://purl.uniprot.org/uniprot/Q6P4R8

Referrals

(interactor)	[UndirectedInteraction:11304631] UniProt:P25490 <-> UniProt:Q6P4R8 (IntAct) [UndirectedInteraction:11266435] UniProt:Q9Y230 <-> UniProt:Q6P4R8 (IntAct) [UndirectedInteraction:11236107] UniProt:Q9Y5K5 <-> UniProt:Q6P4R8 (IntAct) [UndirectedInteraction:11176955] UniProt:Q9Y265 <-> UniProt:Q6P4R8 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5689578] NFRKB [nucleoplasm]