Reactome | UniProt:Q6NZY7 CDC42EP5

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UniProt:Q6NZY7 CDC42EP5 Show undefined attributes

chain	chain:1-148
checksum	48BC1A9B9307CEEC
comment	FUNCTION Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).SUBUNIT Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.SUBCELLULAR LOCATION The CRIB domain mediates interaction with CDC42.SIMILARITY Belongs to the BORG/CEP family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12382629] RefSeq:NP_659494.2 [DatabaseIdentifier:12289785] Pharos - Targets:Q6NZY7 [DatabaseIdentifier:12271991] PRO:Q6NZY7 [DatabaseIdentifier:12129573] OpenTargets:ENSG00000167617 [DatabaseIdentifier:11844937] HPA:ENSG00000167617-CDC42EP5 [DatabaseIdentifier:11833782] HMDB Protein:HMDBP08321 [DatabaseIdentifier:11791941] GeneCards:CDC42EP5 [DatabaseIdentifier:11701805] ENSEMBL:ENST00000617756 [DatabaseIdentifier:11701803] ENSEMBL:ENST00000301200 [DatabaseIdentifier:11701802] ENSEMBL:ENST00000611094 [DatabaseIdentifier:11701804] ENSEMBL:ENST00000619217 [DatabaseIdentifier:11579106] ENSEMBL:ENSP00000301200 [DatabaseIdentifier:11579104] ENSEMBL:ENSP00000479726 [DatabaseIdentifier:11579103] ENSEMBL:ENSP00000484158 [DatabaseIdentifier:11579105] ENSEMBL:ENSP00000484985 [DatabaseIdentifier:11478949] ENSEMBL:ENSG00000273622 [DatabaseIdentifier:11478950] ENSEMBL:ENSG00000278444 [DatabaseIdentifier:11478947] ENSEMBL:ENSG00000167617 [DatabaseIdentifier:11478948] ENSEMBL:ENSG00000273633
databaseName	UniProt
dbId	220238
description	recommendedName: Cdc42 effector protein 5 alternativeName: Binder of Rho GTPases 3
displayName	UniProt:Q6NZY7 CDC42EP5
geneName	CDC42EP5 BORG3 CEP5
identifier	Q6NZY7
isSequenceChanged	false
keyword	Cell shape Cytoplasm Cytoskeleton Membrane Methylation Proteomics identification Reference proteome
modified	[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType	Protein
name	CDC42EP5
otherIdentifier	11720166_at 148170 16875518 227850_3p_x_at 227850_PM_x_at 227850_x_at 3870896 3870897 3870898 3870899 3870900 3870901 3870905 3870906 78567_at 8039273 A_24_P44916 A_33_P3342235 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0007254 GO:0007266 GO:0008360 GO:0012505 GO:0016020 GO:0030838 GO:0031267 GO:0031274 HMNXSV003052589 Hs.29759.1.A1_3p_at Hs.29759.1.A1_3p_x_at ILMN_1774982 TC19001849.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5692655] p-CDC42EP5 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5692687] CDC42EP5 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12741848] UCSC:Q6NZY7 CDC42EP5 [ReferenceDNASequence:12114210] OMIM:609171 CDC42EP5 [ReferenceDNASequence:12058461] NCBI Gene:148170 CDC42EP5 [ReferenceDNASequence:11974368] Monarch:148170 CDC42EP5 [ReferenceDNASequence:11884979] KEGG:hsa:148170 CDC42EP5 [ReferenceDNASequence:11823616] HGNC:17408 CDC42EP5 [ReferenceDNASequence:11437122] dbSNP Gene:148170 CDC42EP5 [ReferenceDNASequence:11419865] CTD Gene:148170 CDC42EP5 [ReferenceDNASequence:11400040] COSMIC - genes:CDC42EP5 CDC42EP5 [ReferenceDNASequence:11344579] BioGPS Gene:148170 CDC42EP5 [ReferenceDNASequence:ensembl:ENSG00000167617] ENSEMBL:ENSG00000167617 CDC42EP5
referenceTranscript	[ReferenceRNASequence:12564404] RefSeq:NM_145057.3 CDC42EP5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BORG3_HUMAN B0VJZ2 Q8TB51
sequenceLength	148
species	[Species:48887] Homo sapiens
stId	uniprot:Q6NZY7
url	http://purl.uniprot.org/uniprot/Q6NZY7

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5692655] p-CDC42EP5 [cytosol] [EntityWithAccessionedSequence:R-HSA-5692687] CDC42EP5 [cytosol]
(referenceSequence)	[ModifiedResidue:5692657] phosphorylated residue at unknown position

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