UniProt:Q6NZY4 ZCCHC8

chain
  • initiator methionine:1
  • chain:2-707
checksum 7BE6E30F919A4771
comment
  • FUNCTION Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579).SUBUNIT Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex. Component of the nuclear exosome targeting (NEXT) complex composed of MTREX, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:27871484, PubMed:27905398). Interacts with proteins involved in RNA processing and degradation such as MTREX and RBM7; interaction with MTREX enhances MTREX RNA helicase activity and bridges between RBM7 and MTREX (PubMed:16263084, PubMed:27871484, PubMed:27905398). Interacts with TERC, the telomerase RNA component (PubMed:31488579).INTERACTION Excluded from nucleolus.ALTERNATIVE PRODUCTS Slight accumulation in cells entering S phase of the cell cycle.DOMAIN The C-terminal part (659-707) contributes to MTREX RNA helicase activity, in part, by enhancing its RNA-dependent ATPase activity.PTM Phosphorylation at Thr-492 by GSK3 is triggered in cells entering mitosis; this phosphorylation is greatly enhanced by nocodazole treatment, but reduced by lithium.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ZCCHC8 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 257283
description
  • recommendedName: Zinc finger CCHC domain-containing protein 8 alternativeName: TRAMP-like complex RNA-binding factor ZCCHC8
displayName UniProt:Q6NZY4 ZCCHC8
geneName
  • ZCCHC8
identifier Q6NZY4
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Coiled coil
  • Disease variant
  • Isopeptide bond
  • Metal-binding
  • mRNA processing
  • mRNA splicing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Spliceosome
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • ZCCHC8
otherIdentifier
  • 11729668_at
  • 16771727
  • 218478_PM_s_at
  • 218478_s_at
  • 230786_PM_at
  • 230786_at
  • 3475680
  • 3475681
  • 3475682
  • 3475683
  • 3475684
  • 3475685
  • 3475686
  • 3475687
  • 3475689
  • 3475690
  • 3475692
  • 3475693
  • 3475694
  • 3475695
  • 3475696
  • 3475697
  • 3475698
  • 3475699
  • 3475700
  • 3475701
  • 3475705
  • 3475706
  • 3475707
  • 3475708
  • 3475709
  • 3475710
  • 3475711
  • 3475712
  • 3475713
  • 3475714
  • 55596
  • 56080_at
  • 64115_at
  • 7967287
  • A_23_P64669
  • GE56817
  • GE898864
  • GO:0000398
  • GO:0003676
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0006396
  • GO:0006397
  • GO:0008270
  • GO:0008380
  • GO:0016071
  • GO:0016073
  • GO:0016076
  • GO:0016604
  • GO:0031124
  • GO:0031499
  • GO:0046872
  • GO:0071013
  • GO:0180034
  • HMNXSV003009698
  • Hs.99298.0.A1_3p_at
  • ILMN_1792092
  • PH_hs_0031167
  • TC12002074.hg
  • g8922133_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ZCHC8_HUMAN
  • Q7L2P6
  • Q8N2K5
  • Q96SK7
  • Q9NSS2
  • Q9NSS3
sequenceLength 707
species [Species:48887] Homo sapiens
stId uniprot:Q6NZY4
url http://purl.uniprot.org/uniprot/Q6NZY4
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